{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:13:22Z","timestamp":1788012802114,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002830","name":"Centre National d\u2019Etudes Spatiales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000844","name":"European Space Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Bulletin"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dietary countermeasures to mitigate detrimental spaceflight\u2010induced effects on bone health would alleviate the requirements and the consequences imposed by other types of countermeasures for this risk. We hypothesised that antioxidant supplementation during 60\u2009days of 6\u00b0 head\u2010down tilt bed rest (HDBR), an analogue of spaceflight, would have a protective effect on bone mineral density (BMD), content (BMC) and bone structure parameters. An exploratory, randomised, controlled, single\u2010blind intervention trial was conducted in a parallel design with 20 healthy male volunteers (age 34\u2009\u00b1\u20098 y, weight 74\u2009\u00b1\u20096\u2009kg). The study included 14\u2009days of baseline data collection (BDC) before bed rest, followed by 60\u2009days of HDBR and a 14\u2010day recovery period. Ten subjects in the antioxidant group received a supplement (741\u2009mg\/d polyphenols, 2.1\u2009g\/d omega\u20103 fatty acids, 168\u2009mg\/d vitamin E and 80\u2009\u03bcg\/d selenium) daily. Ten subjects in the control group received no supplement. The diet was consistent with dietary reference intakes, individually tailored based on the subject's bodyweight and strictly controlled. We measured whole\u2010body, lumbar spine and femur BMD and BMC, as well as BMD of the cortical and trabecular compartments of the distal radius and tibia, and cortical and trabecular thickness during BDC, HDBR and recovery. Data were analysed using linear mixed models. The supplementation of an antioxidant cocktail did not mitigate the deteriorating effects of HDBR on BMD, BMC and bone structure parameters. Our findings do not support a recommendation for antioxidant supplementation for astronauts.<\/jats:p>","DOI":"10.1111\/nbu.12619","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T04:10:50Z","timestamp":1682655050000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60\u2009days of 6\u00b0 head\u2010down tilt bed rest: Results from a randomised controlled trial"],"prefix":"10.1111","volume":"48","author":[{"given":"Katharina","family":"Austermann","sequence":"first","affiliation":[{"name":"Institute of Nutrition and Food Sciences, Nutritional Physiology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Baecker","sequence":"additional","affiliation":[{"name":"IU International University of Applied Sciences  Bad Reichenhall, Erfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara R.","family":"Zwart","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Community Health University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Fimmers","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry, Informatics and Epidemiology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stehle","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Sciences, Nutritional Physiology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Human Health and Performance Directorate NASA Lyndon B. Johnson Space Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-911X","authenticated-orcid":false,"given":"Martina","family":"Heer","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Sciences, Nutritional Physiology University of Bonn  Bonn Germany"},{"name":"IU International University of Applied Sciences  Bad Reichenhall, Erfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45600-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00071"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.482"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040871"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab036"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"215","article-title":"Bone structure and density via HR\u2010pQCT in 60d bed\u2010rest, 2\u2010years recovery with and without countermeasures","volume":"11","author":"Belavy D.L.","year":"2011","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.06.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.057505"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2021.03.026"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.638669"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00021.2014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00018.2018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2015.10.017"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.5.999"},{"key":"e_1_2_10_16_1","unstructured":"Food and Nutrition Board of the Institute of Medicine National Academies. 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