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A genotype\u2010based personalised approach to dietary recommendations may motivate young adults to maintain or adopt positive dietary behaviours. The aim of the present study was to determine the efficacy of genotype\u2010based personalised dietary and physical activity advice on healthy eating motivation in young adults. Participants were young adults (<jats:italic>n<\/jats:italic>\u2009=\u2009153), aged 18\u201325\u2009years. Baseline measures (participant characteristics, height, weight, body mass index [BMI], body fat percentage [BF%], healthy eating motivation and physical activity) were collected. Participants were genotyped for a SNP in the <jats:italic>FTO<\/jats:italic> gene (rs99396090) and randomly allocated (stratified for genotype) to three different groups (1. Genotype\u2010based personalised advice: dietary and physical activity advice based on genotype, BMI and reported physical activity; 2. Non\u2010genotype\u2010based personalised advice: dietary and physical activity advice based on BMI and reported physical activity; 3. Control: no advice). A week after receipt of advice delivered via email, participants completed the healthy eating motivation questionnaire for a second time. Genotype\u2010based personalised dietary advice did not affect healthy eating motivation: when participants were analysed across the whole group (<jats:italic>p<\/jats:italic>\u2009=\u20090.417), when analysed according to those informed of a risk or non\u2010risk\u2010associated genotype (<jats:italic>p<\/jats:italic>\u2009=\u20090.287), or when analysed according to those with a BMI (&gt;25\u2009kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.336) or BF% (male &gt;18%, female &gt;31%; <jats:italic>p<\/jats:italic>\u2009=\u20090.387) outside the healthy range. There was also no significant difference in healthy eating motivation at 1\u2010week in the control or non\u2010genotype\u2010based advice groups. Genotype\u2010based personalised advice for the prevention of obesity did not affect healthy eating motivation in this group of healthy, young adults.<\/jats:p>","DOI":"10.1111\/nbu.12710","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T09:34:41Z","timestamp":1728898481000},"page":"526-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A randomised controlled trial to determine the effect of genotype\u2010based personalised diet and physical activity advice for <i>FTO<\/i> genotype (rs9939609) delivered via email on healthy eating motivation in young adults"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5402","authenticated-orcid":false,"given":"Alexandra","family":"King","sequence":"first","affiliation":[{"name":"Faculty of Sport Technology and Health Sciences, St Mary's University  Twickenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4454-4854","authenticated-orcid":false,"given":"Mark","family":"Glaister","sequence":"additional","affiliation":[{"name":"Faculty of Sport Technology and Health Sciences, St Mary's University  Twickenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-9804","authenticated-orcid":false,"given":"Kate","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Faculty of Sport Technology and Health Sciences, St Mary's University  Twickenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Nixon","sequence":"additional","affiliation":[{"name":"Faculty of Sport Technology and Health Sciences, St Mary's University  Twickenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-1269","authenticated-orcid":false,"given":"Leta","family":"Pilic","sequence":"additional","affiliation":[{"name":"Optimyse Nutrition LTD  Twickenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-6324","authenticated-orcid":false,"given":"Yiannis","family":"Mavrommatis","sequence":"additional","affiliation":[{"name":"Lake Lucerne Institute  Vitznau Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.appet.2017.08.021"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1016\/0749-5978(91)90020-T"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1017\/S1368980020004152"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1056\/NEJM199005243222101"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1016\/S2213-8587(21)00088-7"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1017\/S0029665114001633"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1002\/oby.21422"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.3945\/jn.111.143826"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1186\/1471-2458-12-404"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1080\/17437199.2014.941722"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1186\/s12966-015-0173-9"},{"volume-title":"UK chief medical Officers' physical activity guidelines","year":"2019","author":"Department of Health and Social Care","key":"e_1_2_10_13_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1111\/jasp.12439"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1016\/j.amepre.2014.07.035"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.3945\/ajcn.2008.26847"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1158\/1055-9965.EPI-04-0913"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1093\/ajcn\/72.3.694"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1371\/journal.pmed.1002185"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.2337\/dc12-0884"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1186\/s12263-017-0584-0"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1159\/000358413"},{"unstructured":"Health Survey for England. 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