{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:30:13Z","timestamp":1792467013675,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000557","name":"British Nutrition Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000557","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nutrition Bulletin"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Manipulation of the mouse gut microbiome has been shown to increase gut\u2010derived short\u2010chain fatty acids and improve exercise capacity. Associations between exercise performance and gut microbiome composition and metabolites have also been identified in human studies. Yet there is little direct evidence that prebiotics are able to increase acetate production and improve exercise capacity in human participants. We conducted a randomised controlled cross\u2010over trial with 21 healthy and active males (35.0\u2009\u00b1\u20096.9\u2009years; 24.4\u2009\u00b1\u20092.7\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) to investigate the effect of 15\u2009g of inulin (prebiotic) on exercise performance (15\u2009km cycle time trial), compared to placebo. Time to completion of a 15\u2009km time trial was the primary outcome, while plasma acetate concentration and markers of inulin fermentation (breath H\n                    <jats:sub>2<\/jats:sub>\n                    concentration) and muscle oxygenation were measured to explore potential mechanisms of action. Time to complete the 15\u2009km time trial was not affected by inulin mean difference between inulin and placebo trials: (\u221210.37\u2009s, 95% CI [\u2212150.8, 130.1\u2009s],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.884). The marker of inulin fermentation (H\n                    <jats:sub>2<\/jats:sub>\n                    concentration increase from baseline) was significantly higher in inulin compared to placebo condition (+42.61\u2009ppm, 95% CI [30.04, 55.19],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001 and +31.13\u2009ppm, 95% CI [3.73, 58.51],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029, respectively), but plasma acetate concentration did not differ between conditions. Likewise, markers of muscle oxygenation were not different between inulin and placebo. Our current results do not support the acute use of prebiotics to improve exercise performance in adults. Possible explanations for the absence of ergogenic effects may be that the timing between prebiotic ingestion and exercise was too short to allow for complete fermentation into acetate, participants were in a fasted rather than a fed state, or that the single dose of supplement was insufficient. These factors, together with advanced methods (stable isotope studies) should be investigated in a follow\u2010up study to elucidate the fate and role of colonic\u2010derived acetate during exercise.\n                  <\/jats:p>","DOI":"10.1111\/nbu.70010","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:14:44Z","timestamp":1747872884000},"page":"447-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Role of Fermentable Fibre on Endurance Exercise Capacity: A Randomised Crossover Trial of Inulin Supplementation"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4896-7598","authenticated-orcid":false,"given":"L.","family":"Torquati","sequence":"first","affiliation":[{"name":"Public Health and Sport Sciences, Medical School University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Power","sequence":"additional","affiliation":[{"name":"Natural Sciences, Faculty of Environment, Science and Economy University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1926-2434","authenticated-orcid":false,"given":"T.","family":"Pons","sequence":"additional","affiliation":[{"name":"Natural Sciences, Faculty of Environment, Science and Economy University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-9212","authenticated-orcid":false,"given":"J.","family":"Bowtell","sequence":"additional","affiliation":[{"name":"Public Health and Sport Sciences, Medical School University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001495"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106251"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313627"},{"key":"e_1_2_9_6_1","unstructured":"Beneo GmbH.2024.\u201cFunctional Fibres\u2014Inulin.\u201dhttps:\/\/www.beneo.com\/human\u2010nutrition\/human\u2010nutrition\u2010products\/functional\u2010fibres\/inulin."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.suppl_1.S137"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.05.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115440"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272613"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02546-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13159"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306534"},{"key":"e_1_2_9_14_1","volume-title":"ESSA'S Student Manual for Health, Exercise and Sport Assessment","author":"Coombes J.","year":"2020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2021.1933199"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00044\u201000018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-022-00513-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0189-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092193"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.6.E1144"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.116"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","unstructured":"Gibson G. 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