{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T17:59:01Z","timestamp":1771351141534,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurology &amp; Clinical Neurosc"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because fungi usually spread from the paranasal sinuses to the orbital apex in invasive fungal sinusitis (<jats:styled-content style=\"fixed-case\">IFS<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">IFS<\/jats:styled-content> often presents as an orbital apex syndrome (<jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content>) characterized by dysfunction of cranial nerves II, III, IV, V1, and VI. We report a case of sphenoid sinus mucormycosis that presented as isolated retrobulbar optic neuropathy. A 94\u2010year\u2010old woman presented with acute blindness in the right eye. Examination revealed the absence of light perception and pupillary reflex in the right eye. Head <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> showed a mass in the right sphenoid sinus, which was contiguous with the right optic nerve. She underwent endoscopic surgery, and a histopathological diagnosis of mucormycosis was established. Treatment with intravenous liposomal amphotericin B reduced the size of the mass. She has survived for more than 1 year without recurrence. Clinicians should consider that <jats:styled-content style=\"fixed-case\">IFS<\/jats:styled-content> can present as isolated retrobulbar optic neuropathy.<\/jats:p>","DOI":"10.1111\/ncn3.12216","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T13:39:00Z","timestamp":1530106740000},"page":"146-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis"],"prefix":"10.1111","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-9150","authenticated-orcid":false,"given":"Tatsuhiko","family":"Sano","sequence":"first","affiliation":[{"name":"Department of Neurology JA Toride Medical Center Toride Ibaraki Japan"},{"name":"Department of Neurology and Neurological Sciences Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zen","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology JA Toride Medical Center Toride Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Neurology JA Toride Medical Center Toride Ibaraki Japan"},{"name":"Department of Neurology and Neurological Sciences Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyobumi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Neurology JA Toride Medical Center Toride Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iichiroh","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Pathology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology JA Toride Medical Center Toride Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tomimitsu","sequence":"additional","affiliation":[{"name":"Department of Neurology JA Toride Medical Center Toride Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzo","family":"Shintani","sequence":"additional","affiliation":[{"name":"Department of Neurology JA Toride Medical Center Toride Ibaraki 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