{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:36Z","timestamp":1787015796632,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurology &amp; Clinical Neurosc"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurological involvement associated with SARS\u2010CoV\u20102 infection has been reported from different regions of the world. However, data from South East Asia are scarce. We described the neurological manifestations and their associated factors among the hospitalized COVID\u201019 patients from an academic tertiary hospital in Malaysia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional observational study of hospitalized COVID\u201019 patients was conducted. The neurological manifestations were divided into the self\u2010reported central nervous system (CNS) symptoms, stroke associated symptoms, symptoms of encephalitis or encephalopathy and specific neurological complications. Multiple logistic regression was performed using demographic and clinical variables to determine the factors associated with outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 156 hospitalized COVID\u201019 patients with mean age of 55.88\u2009\u00b1\u20096.11 (SD) years, 23.7% developed neurological complications, which included stroke, encephalitis and encephalopathy. Patients with neurological complications were more likely to have diabetes mellitus (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.033), symptoms of stroke [limb weakness (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), slurred speech (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001)]; and encephalitis or encephalopathy [confusion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), forgetfulness (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006) and seizure (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019)]. Unvaccinated patients had a 4.25\u2010fold increased risk of having neurological complications (adjusted OR\u00a0=\u00a04.25; 95% CI: 1.02, 17.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.047). Anosmia and dysgeusia were less associated with neurological complications (adjusted OR\u00a0=\u00a00.22; 95% CI: 0.05, 0.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044). The odds of neurological complications were increased by 18% in patients with leukocytosis (adjusted OR\u00a0=\u00a01.18, 95% CI: 1.003,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0460).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stroke, encephalitis and encephalopathy were the common neurological complications from our study. Diabetes mellitus, presence of symptoms of stroke, symptoms of encephalitis or encephalopathy, leukocytosis, and being unvaccinated against COVID\u201019 were the associated risk factors of developing neurological complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ncn3.12677","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T21:57:57Z","timestamp":1666389477000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neurological manifestations in\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 infection: A single\u2010center cross\u2010sectional study in Malaysia"],"prefix":"10.1111","volume":"11","author":[{"given":"Hui Jan","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine The National University of Malaysia  Kuala Lumpur 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