{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:43:14Z","timestamp":1697276594279},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The usefulness of the absolute N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010ProBNP) concentration and its digit number for screening for cardiac disease was explored in new haemodialysis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study involving 71 (68\u2009\u00b1\u200914 years, 83% male) new dialysis patients was conducted. Receiver operator characteristic curve analysis was performed to identify the cutoff level of NT\u2010proBNP for identifying cardiac disease at the start of dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median NT\u2010proBNP concentration was 6576\u2009pg\/mL just before the first dialysis session and its mean digit number was 4.3\u2009\u00b1\u20090.6. Overall, 67%, 52%, 9% and 35% of patients had left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) hypertrophy, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dilatation, systolic dysfunction and significant coronary artery disease, respectively. <jats:styled-content style=\"fixed-case\">NT\u2010proBNP<\/jats:styled-content> levels of about 6000, 10\u2009000 and 14\u2009000\u2009pg\/mL were the best cutoff levels for the diagnosis of coronary artery disease (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>, 0.754; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> systolic dysfunction (area under the curve (<jats:styled-content style=\"fixed-case\">AUC)<\/jats:styled-content>, 0.765, <jats:italic>P<\/jats:italic>\u2009=\u20090.001) and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dilatation (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>, 0.685, <jats:italic>P<\/jats:italic>\u2009=\u20090.008), respectively. Interestingly, 4.5 was the best digit number cutoff for all cardiac abnormalities. These findings suggest that a digit number of 5 or more means a potentially high risk for cardiovascular disease and a digit number of 3 or less means a relatively low risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The NT\u2010proBNP concentration just before the first dialysis session is a useful tool for screening for cardiac abnormalities. Considering the wide variation of the NT\u2010proBNP cutoff levels depending on each cardiac abnormality, the digit number could be potentially easier to use for initial risk stratification for cardiac disease in new dialysis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12063","type":"journal-article","created":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T10:41:57Z","timestamp":1365676917000},"page":"497-504","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of N\u2010terminal pro\u2010brain natriuretic peptide digit number for screening of cardiac disease in new haemodialysis patients"],"prefix":"10.1111","volume":"18","author":[{"given":"Masaki","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Joki","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of Cardiology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takasuke","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Dialysis Nissan Tamagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hirahata","sequence":"additional","affiliation":[{"name":"Hirahata Clinic  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Division of Dialysis Nissan Tamagawa Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Hase","sequence":"additional","affiliation":[{"name":"Division of Nephrology Toho University Ohashi Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.01050.x"},{"key":"e_1_2_6_3_1","first-page":"723","article-title":"Atherosclerosis in ckd: Differences from the general population","volume":"6","author":"Drueke TB","year":"2010","journal-title":"Nat. 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