{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:32:04Z","timestamp":1761129124184},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T00:00:00Z","timestamp":1382486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>neumocystis jirovecii<\/jats:italic> pneumonia (<jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content>) is a severe and life\u2010threatening complication in immunocompromised patients. Trimethoprim\/sulfamethoxazole (<jats:styled-content style=\"fixed-case\">TMP\u2010SMZ<\/jats:styled-content>) is well known for its effectiveness as prophylaxis of <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content>. However, the use of <jats:styled-content style=\"fixed-case\">TMP\u2010SMZ<\/jats:styled-content> is associated with various adverse effects that may not be tolerated by critically ill patients. Caspofungin is recommended for invasive fungal infections, but the treatment of <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content> after solid organ transplantation (<jats:styled-content style=\"fixed-case\">SOT<\/jats:styled-content>) is an off\u2010label use of this drug. In this study, three cases of severe <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content> in renal transplant recipients treated with a combination of caspofungin and low\u2010dose <jats:styled-content style=\"fixed-case\">TMP\u2010SMZ<\/jats:styled-content> were presented. Initial findings indicated that the combined treatment may be beneficial for the treatment of <jats:styled-content style=\"fixed-case\">PJP<\/jats:styled-content> and decrease the incidence of <jats:styled-content style=\"fixed-case\">TMP\u2010SMZ<\/jats:styled-content>\u2010related adverse effects.<\/jats:p>","DOI":"10.1111\/nep.12133","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T13:05:13Z","timestamp":1382533513000},"page":"736-742","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Combination of caspofungin and low\u2010dose trimethoprim\/sulfamethoxazole for the treatment of severe <scp>P<\/scp>neumocystis jirovecii pneumonia in renal transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"Guo\u2010wei","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010jie","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui\u2010ming","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010zhou","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang\u2010gang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong\u2010yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Intensive Care Unit Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/339548"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1995.tb139873.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2003.00018.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/508282"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01530.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000280546.91617.6c"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-933433"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-0065-z"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.377"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01559.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032588"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1128\/JCM.38.9.3161-3164.2000","article-title":"Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy","volume":"38","author":"Takahashi T","year":"2000","journal-title":"J. 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