{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:12:23Z","timestamp":1792271543703,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic antibody\u2010mediated rejection (<jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>) in renal transplant patients has poor allograft outcomes. However, treatment strategy has not been established yet. Herein, we present short\u2010term outcomes of combination therapy for <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified nine patients with <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> or suspicious <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> who were treated with antihumoral therapy from 2010 to 2011 and analyzed their medical records retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients had <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>, and four patients had suspicious <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>. Severe transplant glomerulopathy (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) was observed in seven patients. The estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) was decreased in all patients before treatment. We used three different treatment regimens: (i) high\u2010dose intravenous immunoglobulin (<jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>) and rituximab; (ii) high\u2010dose <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>, rituximab, and bortezomib; and (iii) plasmapheresis with low\u2010dose <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>, rituximab and bortezomib. After treatment with one of these three regimens, graft function improved or stabilized in six patients, whereas three patients showed further deterioration of <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>. The third regimen suppressed deterioration of renal function in all patients. Most patients showed no progression of proteinuria. Infectious complications due to <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>neumocystis jirovecii<\/jats:italic> pneumonia and herpes zoster occurred in two patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combination therapy for <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content> might be effective, even in patients with relatively late\u2010stage <jats:styled-content style=\"fixed-case\">CAMR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12157","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T07:18:40Z","timestamp":1378365520000},"page":"820-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes of combination therapy for chronic antibody\u2010mediated rejection in renal transplantation"],"prefix":"10.1111","volume":"18","author":[{"given":"Myung\u2010Gyu","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Korea University Anam Hospital  Seoul Korea"},{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk Yong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayne Cho","family":"Park","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Yeon","family":"Koo","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Cheol","family":"Jeong","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyeun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curie","family":"Ahn","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine  Seoul Korea"},{"name":"Transplantation Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseok","family":"Yang","sequence":"additional","affiliation":[{"name":"Transplantation Center Seoul National University Hospital  Seoul Korea"},{"name":"Transplantation Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V123574"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00299.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01895.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000025780.03790.0F"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01836.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02159.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010073"},{"key":"e_1_2_6_9_1","first-page":"302A","article-title":"Pathology, serology and clinical characteristics of 68 patients with chronic humoral renal allograft rejection","volume":"22","author":"Farris AB","year":"2009","journal-title":"Mod. 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