{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:45:49Z","timestamp":1791409549545,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The receptor for advanced glycation end products (<jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content>) has emerged as a central regulator of vascular inflammation and atherosclerosis. Soluble <jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content>) has an anti\u2010inflammatory effect by quenching ligands for <jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content>. On the other hand, extracellular <jats:styled-content style=\"fixed-case\">RAGE<\/jats:styled-content>\u2010binding protein <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>100<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>12 (<jats:styled-content style=\"fixed-case\">EN\u2010RAGE<\/jats:styled-content>) shows a pro\u2010inflammatory effect in a way, but may play pleiotropic roles related to inflammatory process. Therefore, we determined the levels of <jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>100<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>12 in haemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients and evaluated their relationship with vascular calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study with 199 <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients. Plain <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray images of the lateral lumbar spine from all subjects were studied to calculate semiquantitative vascular calcification scores (<jats:styled-content style=\"fixed-case\">VCS<\/jats:styled-content>), as described by <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>auppila. Commercially available enzyme linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA)<\/jats:styled-content> kits were used to quantify the serum concentration of <jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>100<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients were 57.1\u2009\u00b1\u200913.7 years of age; 54.3% were male, 49.2% were diabetic, and 36.2% had a history of cardiovascular disease. In a univariate analysis, serum <jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content> was negatively associated with <jats:styled-content style=\"fixed-case\">VCS<\/jats:styled-content> (log <jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content>, r\u2009=\u2009\u20130.208, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), whereas <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>100<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>12 showed a positive tendency (log <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>100<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>12, r\u2009=\u20090.235, <jats:italic>P<\/jats:italic>\u2009=\u20090.085). Even after adjustments for confounding risk factors, <jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content> was independently associated with <jats:styled-content style=\"fixed-case\">VCS<\/jats:styled-content> (\u03b2\u2009=\u2009\u20131.679, <jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that the circulating <jats:styled-content style=\"fixed-case\">sRAGE<\/jats:styled-content> level was inversely associated with <jats:styled-content style=\"fixed-case\">VCS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients independent of the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>100<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>12 level and the severity of systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12166","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:37:38Z","timestamp":1381750658000},"page":"777-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Circulating levels of soluble receptor for advanced glycation end product are inversely associated with vascular calcification in patients on haemodialysis independent of <scp>S<\/scp>100<scp>A<\/scp>12 (<scp>EN\u2010RAGE<\/scp>) levels"],"prefix":"10.1111","volume":"18","author":[{"given":"Hyung Soo","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wookyung","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ro","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyun","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yong","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Gachon University Gil Medical Center Gachon University of Medicine and Science  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_11.28"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy1001.096358"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04800709"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg414"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.06.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.69.6.986"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.419"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03360410"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2010.11.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000148646"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(97)00106-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.06.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2741\/3700"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2645"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.11.1734"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012626"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200114002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.020"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/2012"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.1.166"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118397"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08310910"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.07.115"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-011-0007-x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CPJ04005X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg513"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.12.028"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329291"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:03:20Z","timestamp":1696269800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,26]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/nep.12166"],"URL":"https:\/\/doi.org\/10.1111\/nep.12166","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,26]]},"assertion":[{"value":"2013-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}