{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:37:35Z","timestamp":1778276255029,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our aim was to evaluate the long\u2010term effect of cinacalcet in patients with hypercalcaemic secondary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">SHPT<\/jats:styled-content>) after renal transplantation (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) in order to expand real\u2010world data in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multicentre, observational, retrospective study in 17 renal transplant units from <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pain. We collected data from renal recipients with hypercalcaemic (calcium &gt;10.2\u2009mg\/dL) <jats:styled-content style=\"fixed-case\">SHPT<\/jats:styled-content> (intact parathyroid hormone (iPTH)\u2009&gt;\u2009120\u2009pg\/mL) who initiated cinacalcet in the clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 193 patients with a mean (standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>)) age of 52 (12) years, 58% men. Cinacalcet treatment was initiated at a median of 20 months after <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> (median dose 30\u2009mg\/day). Mean calcium levels decreased from a mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) of 11.1 (0.6) at baseline to 10.1 (0.8) at 6 months (9.0% reduction, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Median iPTH was reduced by 23.0% at 6 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.0005) and mean phosphorus levels increased by 11.1% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The effects were maintained up to 3\u2010years. No changes were observed in renal function or anticalcineurin drug levels. Only 4.1% of patients discontinued cinacalcet due to intolerance and 1.0% due to lack of efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In renal transplant patients with hypercalcaemic <jats:styled-content style=\"fixed-case\">SHPT<\/jats:styled-content>, cinacalcet controlled serum calcium, iPTH and phosphorus levels up to 3 years. Tolerability was good.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12186","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T07:14:59Z","timestamp":1387178099000},"page":"84-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cinacalcet for hypercalcaemic secondary hyperparathyroidism after renal transplantation: a multicentre, retrospective, 3\u2010year study"],"prefix":"10.1111","volume":"19","author":[{"given":"Jose\u2010Vicente","family":"Torregrosa","sequence":"first","affiliation":[{"name":"Nephrology Service and Renal Transplant Unit Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital 12 de Octubre  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan 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