{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:48:41Z","timestamp":1694504921159},"reference-count":8,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In patients with end\u2010stage kidney disease (<jats:styled-content style=\"fixed-case\">ESKD<\/jats:styled-content>) secondary to mesangiocapillary glomerulonephritis (<jats:styled-content style=\"fixed-case\">MCGN<\/jats:styled-content>), recurrent disease post transplantation is a common cause of graft loss. We report a case of a 33\u2010year\u2010old female with <jats:styled-content style=\"fixed-case\">ESKD<\/jats:styled-content> due to idiopathic <jats:styled-content style=\"fixed-case\">MCGN<\/jats:styled-content> who developed recurrent disease in two consecutive renal allografts. Recurrent disease was diagnosed two months after receiving her primary transplant from a live related donor. Oral cyclophosphamide was initiated but discontinued after 10 months due to cystitis. This was followed by rapid deterioration in her renal function. Despite salvage therapy with rituximab, the graft was lost 2 years post transplantation. After 7 years on haemodialysis, the patient received a second graft from a deceased donor. Recurrent <jats:styled-content style=\"fixed-case\">MCGN<\/jats:styled-content> was once again diagnosed one year post transplantation. She was treated with plasma exchange and rituximab. Despite ongoing nephrotic range proteinuria, her graft function remained stable 2 years post transplantation. The optimal therapy for recurrent <jats:styled-content style=\"fixed-case\">MCGN<\/jats:styled-content> is unknown at this stage. It is hoped that a better understanding of its pathogenesis will enable the development of more effective and targeted therapies.<\/jats:p>","DOI":"10.1111\/nep.12191","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T11:12:39Z","timestamp":1390821159000},"page":"6-9","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In search of an effective treatment for recurrent mesangiocapillary glomerulonephritis in the renal allograft"],"prefix":"10.1111","volume":"19","author":[{"given":"Michael MX","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Nephrology Monash Medical Centre  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Monash Medical Centre  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R","family":"Mulley","sequence":"additional","affiliation":[{"name":"Department of Nephrology Monash Medical Centre  Clayton Victoria Australia"},{"name":"Department of Medicine Monash University  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.09.021"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318218e94e"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1108178"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010080795"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70211-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.09.079"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12901211"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12191","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T15:19:52Z","timestamp":1694445592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":8,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/nep.12191"],"URL":"https:\/\/doi.org\/10.1111\/nep.12191","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]},"assertion":[{"value":"2013-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}