{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:13:37Z","timestamp":1696227217203},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term haemodialysis patients may be at risk of hydrosoluble vitamin deficiencies. This study aimed to test the hypothesis that in patients with serum <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12\u2009&lt;\u2009300\u2009pmol\/L, intramuscular hydroxocobalamin reduces erythropoietin requirements whilst maintaining haemoglobin concentrations (<jats:styled-content style=\"fixed-case\">Hb<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study design was prospective, non\u2010randomized, open label, with single group assignment. In 61 patients hydroxocobalamin 1000\u2009\u03bcg was given weekly for 3 weeks and erythropoietin dose adjusted to target a <jats:styled-content style=\"fixed-case\">Hb<\/jats:styled-content> of 11\u201312\u2009g\/L. The primary outcome was the change in erythropoietin requirements at 2 years. Secondary outcomes included assessment of change in biochemical or clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The erythropoietin dose reduced from 11\u2009000\u2009\u00b1\u20097000 (10\u2009000) IU to 5000\u2009\u00b1\u20096000 (3000) IU per week (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) with no change in <jats:styled-content style=\"fixed-case\">Hb<\/jats:styled-content> 116\u2009\u00b1\u200916 (117) g\/L before and after 114\u2009\u00b1\u200915 (113) g\/L (<jats:italic>P<\/jats:italic>\u2009=\u20090.488) hydroxocobalamin supplementation. Serum albumin rose from 35\u2009\u00b1\u20094 (35) g\/L to 36\u2009\u00b1\u20094 (36) g\/L (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). A significant rise in red cell folate (<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>) and serum vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12 levels was observed. Serum ferritin rose despite a reduction in intravenous iron usage and no significant change in c\u2010reactive protein or transferrin saturation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>12\u2009&lt;\u2009300\u2009pmol\/L, following treatment with hydroxocobalamin there was reduced erythropoietin requirements, maintained <jats:styled-content style=\"fixed-case\">Hb<\/jats:styled-content> and a small but significant rise in the serum albumin. <jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content> may be low in haemodialysis patients with metabolic cobalamin deficiency and rises significantly after supplementation. Hydroxocobalamin supplementation may have the potential to reduce the cost of anaemia management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12205","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T09:44:29Z","timestamp":1389779069000},"page":"164-171","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hydroxocobalamin supplementation and erythropoisis stimulating agent hyporesponsiveness in haemodialysis patients"],"prefix":"10.1111","volume":"19","author":[{"given":"John P","family":"Killen","sequence":"first","affiliation":[{"name":"Department of Renal Medicine Cairns Hospital  North Cairns Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa L","family":"Brenninger","sequence":"additional","affiliation":[{"name":"Department of Nutrition Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563212473279"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.158154"},{"key":"e_1_2_7_4_1","first-page":"979","article-title":"Vitamin B12 deficiency","volume":"67","author":"Oh R","year":"2003","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1113996"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1834"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.001370"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365519709060029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2199-9_16"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105495"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168443"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00234.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.047"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2181"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196810172791602"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D189"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00371-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075569"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021717"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00230.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000189546"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.24.012003.132440"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/clinchem\/46.8.1277","article-title":"Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate","volume":"46","author":"Klee GG","year":"2000","journal-title":"Clin. Chem."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.8.1622"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27230C"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00632.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200052997384"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.128678"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1681\/ASN.V131265","article-title":"Plasma total homocysteine levels among patients undergoing nocturnal versus standard hemodialysis","volume":"13","author":"Friedman AN","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1051095"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.32800"},{"key":"e_1_2_7_32_1","first-page":"10","article-title":"Parenteral vitamin B12 therapy of hyperhomocysteinemia in end\u2010stage renal disease","volume":"27","author":"Hoffer LJ","year":"2004","journal-title":"Clin. Invest. Med."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.490"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.5.565"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2007.00810.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0465"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096149"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.12.035"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(00)91351-9"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2005.04.027"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP75336"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1304350"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013367"},{"key":"e_1_2_7_44_1","volume-title":"Hematology","author":"Besa EC","year":"1992"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987056"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00270.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03330807"},{"key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1681\/ASN.V75728","article-title":"Hypoalbuminemia, cardiac morbidity, and mortality in end\u2010stage renal disease","volume":"7","author":"Foley RN","year":"1996","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.165"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9631845"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.20754"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90394-7"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90176-0"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00658.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03860609"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:32:33Z","timestamp":1696167153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,17]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/nep.12205"],"URL":"https:\/\/doi.org\/10.1111\/nep.12205","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,17]]},"assertion":[{"value":"2013-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}