{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:25:35Z","timestamp":1768037135811,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Some patients with severe immunoglobulin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> nephropathy (<jats:styled-content style=\"fixed-case\">IgAN<\/jats:styled-content>) are resistant to multi\u2010drug combination therapy; however, there have been few reports on the risk factors for non\u2010responsiveness to treatment for severe <jats:styled-content style=\"fixed-case\">IgAN<\/jats:styled-content>. We, therefore, evaluated the risk factors for non\u2010responsiveness to treatment in cases of severe <jats:styled-content style=\"fixed-case\">IgAN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data on 44 children who had been diagnosed with <jats:styled-content style=\"fixed-case\">IgAN<\/jats:styled-content> with diffuse mesangial proliferation and treated with multi\u2010drug combination therapy. The children were divided into two groups based on the prognosis at the latest follow\u2010up. Group 1 consisted of 30 children with normal urine and nine children with minor urinary abnormalities and Group 2 consisted of four children with persistent nephropathy and one child with renal insufficiency. The clinical, laboratory, and pathological findings for both groups were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The age at the onset in Group 2 was higher than that in Group 1. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>3 deposits and high chronicity index values at the first renal biopsy were more frequently found in Group 2 than in Group 1 patients. <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> deposits, serum <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> and myeloid\u2010related protein (<jats:styled-content style=\"fixed-case\">MRP)<\/jats:styled-content> 8\/14 levels, and glomerular and interstitial <jats:styled-content style=\"fixed-case\">MRP<\/jats:styled-content>8+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68+ scores at the second biopsy were all higher in Group 2 than in Group 1 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results, although based on only a small number of patients in a retrospective study, suggest that age, presence of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>3 deposits and interstitial changes at the onset, and persistent renal inflammatory activation may be risk factors for non\u2010responsiveness to treatment for <jats:styled-content style=\"fixed-case\">IgAN<\/jats:styled-content> with diffuse mesangial proliferation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12232","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T08:52:56Z","timestamp":1395305576000},"page":"384-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Resistance factors for the treatment of immunoglobulin <scp>A<\/scp> nephropathy with diffuse mesangial proliferation"],"prefix":"10.1111","volume":"19","author":[{"given":"Yukihiko","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuto","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"694","article-title":"Les depots intercapillaireis d'IgA\u2010IgG","volume":"74","author":"Berger J","year":"1968","journal-title":"J. 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