{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:35:35Z","timestamp":1777937735355,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Transplant glomerulopathy (TG<\/jats:styled-content>) is included as one of the criteria of chronic active antibody\u2010mediated rejection (c\u2010AMR<\/jats:styled-content>) in B<\/jats:styled-content>anff 09 classification. In this report, we discuss the clinical and pathological analyses of cases of TG<\/jats:styled-content> after renal transplantation.<\/jats:p><\/jats:sec>Patients<\/jats:title>TG<\/jats:styled-content> was diagnosed in 86 renal allograft biopsy specimens (BS<\/jats:styled-content>) obtained from 50 renal transplant patients followed up at our institute between J<\/jats:styled-content>anuary 2006 and O<\/jats:styled-content>ctober 2012. We retrospectively reviewed the data of these 86 BS<\/jats:styled-content> and 50 patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the 50 patients, 42 (84%) had a history of acute rejection (AR<\/jats:styled-content>); of these, 30 (60%) had acute antibody\u2010mediated rejection (a\u2010AMR<\/jats:styled-content>). Among the 86 BS<\/jats:styled-content> of TG<\/jats:styled-content>, the TG<\/jats:styled-content> was mild in 35 cases (cg1 in B<\/jats:styled-content>anff classification), moderate in 28 cases (cg2) and severe in 23 cases (cg3). Peritubular capillaritis was present in 74 BS<\/jats:styled-content> (86%), transplant glomerulitis in 65 (76%), interstitial fibrosis and tubular atrophy (IF<\/jats:styled-content>\/TA<\/jats:styled-content>) in 71 (83%), thickening of the peritubular capillary (PTC<\/jats:styled-content>) basement membrane in 72 (84%), and interstitial inflammation in 40 (47%). C<\/jats:styled-content>4d deposition in the PTC<\/jats:styled-content> was present in 49 BS<\/jats:styled-content> (57%); 39 of these 49 BS<\/jats:styled-content> showed diffuse C<\/jats:styled-content>4d deposits in the PTC<\/jats:styled-content> (C<\/jats:styled-content>4d3), while the remaining 10 BS<\/jats:styled-content> showed focal deposits (C<\/jats:styled-content>4d2). Diffuse C<\/jats:styled-content>4d deposition in the glomerular capillaries (GC<\/jats:styled-content>) was seen in 70 BS<\/jats:styled-content> (81%), while focal C<\/jats:styled-content>4d deposition in the GC<\/jats:styled-content> was seen in 9 (11%). In the assay using plastic beads coated with HLA<\/jats:styled-content> antigen performed in 67 serum samples obtained in the peri\u2010biopsy period, circulating ant\u2010HLA<\/jats:styled-content> alloantibody was detected in 55 (82%); in 33 of the 55 (49%) samples, donor\u2010specific antibodies (DSA<\/jats:styled-content>) were detected. Among our study, the findings in 22 BS<\/jats:styled-content> (26%) fully met the criteria for c\u2010AMR<\/jats:styled-content> in B<\/jats:styled-content>anff \u201909 classification, including TG<\/jats:styled-content>, C<\/jats:styled-content>4d deposition in the PTC<\/jats:styled-content> and presence of DSA<\/jats:styled-content>, while those in 27 BS<\/jats:styled-content> were suspicious of c\u2010AMR<\/jats:styled-content>. Deterioration of the renal allograft function after the biopsies was seen in 31 patients (62%), of which 11 lost their graft.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We suggest that histopathological changes of transplant glomerulopathy might be accompanied by inflammation of the microvasculature, such as transplant glomerulitis and peritubular capillaritis, thickening of the peritubular capillary basement membrane, and circulating anti\u2010HLA<\/jats:styled-content> antibodies. C<\/jats:styled-content>4d deposition in the PTC<\/jats:styled-content> is not always present in biopsy specimens of TG<\/jats:styled-content>. We speculated that C<\/jats:styled-content>4d deposition in the GC<\/jats:styled-content>, rather than that in the PTC<\/jats:styled-content> might be a more characteristic manifestation of TG<\/jats:styled-content>. Many of the patients with TG<\/jats:styled-content> had a history of AR<\/jats:styled-content>. Anti\u2010HLA<\/jats:styled-content> antibody C<\/jats:styled-content>lass II<\/jats:styled-content>, particularly when the antibody was DSA C<\/jats:styled-content>lass II<\/jats:styled-content>, appeared to be associated with the development of TG<\/jats:styled-content>. The prognosis of grafts exhibiting TG<\/jats:styled-content> was not too good even under the currently used immunosuppressive protocol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12243","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T07:26:00Z","timestamp":1400570760000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical and pathological analyses of transplant glomerulopathy cases"],"prefix":"10.1111","volume":"19","author":[{"given":"Tomokazu","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Toki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Omoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuho","family":"Honda","sequence":"additional","affiliation":[{"name":"Pathology II Tokyo Women's Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junki","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Pathology Kawasaki City Tama Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02104.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00299.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02987.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01708.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02159.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365597009137586"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01688.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01836.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01895.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01416.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.112"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V123574"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000025780.03790.0F"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00662.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00710.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01560.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01503.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01691.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01711.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067160"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.043"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.057002154.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000155187.81806.DF"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1681\/ASN.V133754","article-title":"Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation","volume":"13","author":"Abdi R","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035717"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00188-0"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000151632.21551.00"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199701150-00008"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200107150-00016"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T15:20:07Z","timestamp":1694445607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,20]]},"references-count":29,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/nep.12243"],"URL":"https:\/\/doi.org\/10.1111\/nep.12243","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,20]]},"assertion":[{"value":"2014-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}