{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:46:04Z","timestamp":1774525564743,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Abstract<\/jats:title>A 51\u2010year\u2010old woman received an ABO<\/jats:styled-content> blood type\u2010incompatible renal transplant. She was administered rituximab and basiliximab and underwent plasma exchanges for induction therapy, followed by administration of tacrolimus, mycophenolate mofetil and methylprednisolone as maintenance immunosupression therapy. A planned renal biopsy 2 years after transplantation revealed infiltration of plasma cells in the renal interstitium, although there was no \u2018storiform\u2019 fibrosis surrounding these cells. There were also no findings of rejection, BK<\/jats:styled-content> virus nephropathy, or atypical plasma cells. Immunohistochemical stainings showed a large number of IgG4<\/jats:styled-content>\u2010positive plasma cells, most of which expressed kappa\u2010type light chains. A CT<\/jats:styled-content> scan showed a mass at the renal hilum. The serum IgG4<\/jats:styled-content> level was high. Based on these findings, the patient was suspected of having IgG4<\/jats:styled-content>\u2010related kidney disease. Nine months after the biopsy, her serum creatinine level increase to 1.56\u2009mg\/dL and the dose of methylprednisolone was therefore increased to 16\u2009mg\/day. Three months after this increase in steroid, a CT<\/jats:styled-content> scan showed the hilum mass had disappeared. A follow\u2010up biopsy 5 months later showed that infiltration of plasma cells in the renal interstitium had decreased markedly, although focal and segmental severely fibrotic lesions with IgG4<\/jats:styled-content>\u2010positive plasma cells were observed. Serum IgG4<\/jats:styled-content> levels decreased immediately after the increase in steroid dose and remained <100\u2009mg\/dL despite a reduction in methylprednisolone to 6\u2009mg\/day. Serum creatinine levels also remained stable at around 1.6\u2009mg\/dL. To our knowledge, this is the first report of IgG4<\/jats:styled-content>\u2010positive plasma cell\u2010rich tubulointerstitial nephritis mimicking IgG4<\/jats:styled-content>\u2010related kidney disease after kidney transplantation.<\/jats:p>","DOI":"10.1111\/nep.12250","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T07:26:00Z","timestamp":1400570760000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A case of IgG4<\/scp>\u2010positive plasma cell\u2010rich tubulointerstitial nephritis in a kidney allograft mimicking IgG4<\/scp>\u2010related kidney disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Kouhei","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Nephro\u2010Urologic Surgery and Andrology Mie University Graduate School of Medicine Tsu 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