{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:26:14Z","timestamp":1745321174684},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Ministry of Health in China","award":["201002006"],"award-info":[{"award-number":["201002006"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The risk of asymptomatic haematuria and\/or proteinuria development into chronic progressive glomerulonephritis (<jats:styled-content style=\"fixed-case\">CPG<\/jats:styled-content>) is unclear. The indications for renal biopsy and follow\u2010up on these asymptomatic children remain controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, retrospective study was performed to investigate the renal histological features of school\u2010age children with asymptomatic urine abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 112 asymptomatic children's renal biopsy data were studied. Most of the children (71%) received a renal biopsy because of isolated microscopic haematuria (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>), and these children were predominantly (60%) proven to have only mild lesions in the glomeruli. Approximately 30% of the children were biopsied because of asymptomatic proteinuria with or without microscopic haematuria (<jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> or isolated asymptomatic proteinuria (<jats:styled-content style=\"fixed-case\">IP)<\/jats:styled-content>), and these children were mostly (44\u201383%) indicated to have <jats:styled-content style=\"fixed-case\">CPG<\/jats:styled-content>, such as <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> nephropathy, focal segmental glomerulosclerosis, and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lport syndrome. The junior high school students had a greater percentage of <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> than the primary school children. <jats:styled-content style=\"fixed-case\">IgA<\/jats:styled-content> nephropathy was the most common diagnosis in children who received renal biopsy because of <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings indicate that <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content> and especially <jats:styled-content style=\"fixed-case\">HP<\/jats:styled-content> may have a high risk of development into <jats:styled-content style=\"fixed-case\">CPG<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>, however, has a relatively low risk of severe histological lesions. Thus, <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>\u2005<jats:italic>per se<\/jats:italic> might not be suggested as an indication for early renal biopsy. Long\u2010term follow\u2010up is necessary for these asymptomatic children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12260","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T18:21:38Z","timestamp":1397154098000},"page":"426-431","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Renal histological features of school\u2010age children with asymptomatic haematuria and\/or proteinuria: A multicenter study"],"prefix":"10.1111","volume":"19","author":[{"given":"Yihui","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Departent of Nephrology Children's Hospital of Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Renal Division Department of Pediatrics Xinhua Hospital of Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haimei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00852844"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670100043"},{"key":"e_1_2_7_5_1","first-page":"134","article-title":"Mass urinary screening and follow\u2010up for school children in Taiwan Province","volume":"42","author":"Lin CY","year":"2001","journal-title":"Acta Paediatr. 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