{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:39:30Z","timestamp":1791855570579,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Evidence suggests the possibility that pre\u2010existing chronic kidney (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) disease may result in a more severe outcome of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>). The aim of this study was to examine whether<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>enhances the inflammatory response in the kidney, as well as other organs, in response to<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>was induced by 5\/6 nephrectomy (<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>) and<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>by intestinal ischaemia and reperfusion (<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For 6 weeks following<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>there was a progressive increase in serum creatinine with associated development of albuminuria. The increment in creatinine above baseline determination 90\u2009min following<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>was comparable in 5\/6<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>and in the sham 5\/6<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>. Similarly, increased levels of serum alanine transaminase and histomorphological changes in the lungs were observed in the rats exposed to<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>compared with those exposed to sham<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>, with no additional significant impact of 5\/6<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>. In kidney tissue the levels of cytokines\/chemokines were equally elevated regardless of exposure to sham<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>. In lung and liver tissue the levels of cytokines\/chemokines were equally elevated in the rats that were exposed to<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>, regardless of exposure to sham<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that the immediate severity of<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>induced by<jats:styled-content style=\"fixed-case\">IIR<\/jats:styled-content>in rats with<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>is similar to that induced in rats without<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. However, the impact of<jats:styled-content style=\"fixed-case\">Nx<\/jats:styled-content>on the cytokine\/chemokine response after<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>is not uniform in kidney, lung or liver tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12263","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T07:52:51Z","timestamp":1397548371000},"page":"410-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute kidney injury in rats with or without pre\u2010existing chronic kidney disease: Cytokine\/chemokine response"],"prefix":"10.1111","volume":"19","author":[{"given":"Martin","family":"Skott","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University Aarhus Denmark"},{"name":"The Water &amp; Salt Research Center Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"N\u00f8rregaard","sequence":"additional","affiliation":[{"name":"The Water &amp; Salt Research Center Aarhus University Aarhus Denmark"},{"name":"Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Birke\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Palmfeldt","sequence":"additional","affiliation":[{"name":"Research Unit for Molecular Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Hwan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology School of Medicine Kyungpook National University Taegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Fr\u00f8ki\u00e6r","sequence":"additional","affiliation":[{"name":"The Water &amp; Salt Research Center Aarhus University Aarhus Denmark"},{"name":"Institute of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University Aarhus Denmark"},{"name":"The Water &amp; Salt Research Center Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61271-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05571008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329082"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.346"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1681\/ASN.V10122551","article-title":"Chronic reduction in renal mass in the rat attenuates ischemia\/reperfusion injury and does not impair tubular regeneration","volume":"10","author":"Vercauteren SR","year":"1999","journal-title":"J. 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