{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:21:15Z","timestamp":1778034075633,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T00:00:00Z","timestamp":1413072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The angiotensin type 2 (<jats:styled-content style=\"fixed-case\">AT<jats:sub>2<\/jats:sub><\/jats:styled-content>) receptor takes part in the process of ureteric bud during kidney development. Therefore, the gene encoding <jats:styled-content style=\"fixed-case\">AT<jats:sub>2<\/jats:sub><\/jats:styled-content> receptor, the <jats:italic><jats:styled-content style=\"fixed-case\">AGTR2<\/jats:styled-content><\/jats:italic> gene located in the <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> chromosome, is a potential candidate for genetic association with Congenital Anomalies of the Kidney and Urinary Tract (<jats:styled-content style=\"fixed-case\">CAKUT<\/jats:styled-content>). This study aimed to investigate whether <jats:italic><jats:styled-content style=\"fixed-case\">AGTR2<\/jats:styled-content><\/jats:italic> gene polymorphisms are associated with <jats:styled-content style=\"fixed-case\">CAKUT<\/jats:styled-content> in general or even with common phenotypes of <jats:styled-content style=\"fixed-case\">CAKUT<\/jats:styled-content> in a Brazilian sample of paediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 290 paediatric patients with <jats:styled-content style=\"fixed-case\">CAKUT<\/jats:styled-content> and 262 healthy controls from the same geographic area. <jats:styled-content style=\"fixed-case\">TaqMan<\/jats:styled-content> single\u2010nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) genotyping assays for <jats:italic><jats:styled-content style=\"fixed-case\">AGTR2<\/jats:styled-content><\/jats:italic> gene at <jats:italic>rs1403543<\/jats:italic>, <jats:italic>rs3736556, rs35474657, rs5193<\/jats:italic> and <jats:italic>rs5194<\/jats:italic> were performed. The sample was in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ardy\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>einberg <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>quilibrium for all five <jats:styled-content style=\"fixed-case\">SNPs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of <jats:styled-content style=\"fixed-case\">CAKUT<\/jats:styled-content> in general was not significantly associated with the <jats:styled-content style=\"fixed-case\">SNPs<\/jats:styled-content> included in this study. However, when patients were segregated according to major phenotypes, the diagnosis of Ureteropelvic Junction Obstruction (<jats:styled-content style=\"fixed-case\">UPJO<\/jats:styled-content>) was significantly associated with <jats:italic><jats:styled-content style=\"fixed-case\">AGTR2<\/jats:styled-content><\/jats:italic> gene polymorphisms at <jats:italic>rs3736556<\/jats:italic> and at <jats:italic>rs5194<\/jats:italic>. On the other hand, the diagnoses of vesicoureteral reflux and of multicystic dysplastic kidney were not associated with <jats:styled-content style=\"fixed-case\">AGTR2<\/jats:styled-content> gene polymorphisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support that the <jats:italic><jats:styled-content style=\"fixed-case\">AGTR2<\/jats:styled-content><\/jats:italic> gene may contribute to the pathogenesis of <jats:styled-content style=\"fixed-case\">UPJO<\/jats:styled-content> and the genetic origin of <jats:styled-content style=\"fixed-case\">CAKUT<\/jats:styled-content> could vary according to phenotype expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12308","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T08:38:57Z","timestamp":1404463137000},"page":"714-720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of angiotensin type 2 receptor gene polymorphisms with ureteropelvic junction obstruction in <scp>B<\/scp>razilian patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Debora M","family":"Miranda","sequence":"first","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Unity of Pediatric Nephrology Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Augusto Cesar","family":"dos Santos","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Unity of Pediatric Nephrology Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena C","family":"Sarubi","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Bastos\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Valad\u00e3o","family":"Rosa","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabella S","family":"Freitas","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Armando","family":"De Marco","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A","family":"Oliveira","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Unity of Pediatric Nephrology Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-3882","authenticated-orcid":false,"given":"Ana Cristina","family":"Sim\u00f5es e Silva","sequence":"additional","affiliation":[{"name":"INCT\/MM \u2013 National Institute of Science and Technology in Molecular Medicine Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Unity of Pediatric Nephrology Federal University of Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2530-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2684-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834fdbd4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/909083"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2616-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.378"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00147.2009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-2002-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1613"},{"key":"e_1_2_6_11_1","first-page":"2067","article-title":"Early expression of all the components of the renin\u2010angiotensin\u2010system in human development","volume":"149","author":"Sch\u00fctz S","year":"1996","journal-title":"Am. J. Pathol."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80169-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1820-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3180679101"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1999-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041244.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000145252.89427.9E"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.09.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2107-y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03400411"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.19.5444"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2006.00287.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5566.261b"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20297"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069424"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_9.45"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00188.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8256"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2013.06.004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000130564.75008.F5"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:27:39Z","timestamp":1696166859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,12]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/nep.12308"],"URL":"https:\/\/doi.org\/10.1111\/nep.12308","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,12]]},"assertion":[{"value":"2014-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}