{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:51:41Z","timestamp":1768686701788,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30900692"],"award-info":[{"award-number":["30900692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81370844"],"award-info":[{"award-number":["81370844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pujiang Talent Program of Shanghai Municipality","award":["12PJ1403300"],"award-info":[{"award-number":["12PJ1403300"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To investigate whether endothelial nitric oxide synthase (eNOS) gene associate with the progression of autosomal dominant polycystic kidney disease (ADPKD).<\/jats:p><\/jats:sec>Methods<\/jats:title>Databases of EMBASE<\/jats:styled-content>, Pubmed, ISI<\/jats:styled-content>, O<\/jats:styled-content>vid Database, C<\/jats:styled-content>ochrane library and C<\/jats:styled-content>hina National Knowledge Infrastructure were all searched. Associated studies about eNOS<\/jats:styled-content><\/jats:italic> polymorphisms and ADPKD<\/jats:styled-content> were analyzed by meta\u2010analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 11 studies with Glu298Asp<\/jats:styled-content> and 4b\/a polymorphisms were included. A allele of the 4b\/a polymorphism increased the risk of end stage renal disease (ESRD)<\/jats:styled-content> in ADPKD<\/jats:styled-content> (odds ratio (OR)<\/jats:styled-content>\u2009=\u20091.85, 95% confidence interval (CI)<\/jats:styled-content> 1.17\u20132.94, P<\/jats:italic>\u2009=\u20090.009). However, GG<\/jats:styled-content> phenotype of Glu298Asp<\/jats:styled-content> polymorphism neither decreased the ESRD<\/jats:styled-content> risk (OR<\/jats:styled-content>\u2009=\u20090.77, 95% CI<\/jats:styled-content> 0.55\u20131.08, P<\/jats:italic>\u2009=\u20090.13) nor affected the hypertension risk (OR<\/jats:styled-content>\u2009=\u20091.04, 95% CI<\/jats:styled-content> 0.66\u20131.66, P<\/jats:italic>\u2009=\u20090.86). The GG<\/jats:styled-content> phenotype carriers had later ESRD<\/jats:styled-content> age compared with the T<\/jats:styled-content> allele of Glu298Asp<\/jats:styled-content> polymorphism (WMD<\/jats:styled-content>\u2009=\u20092.39; 95% CI<\/jats:styled-content> 1.32\u20133.46; P<\/jats:italic>\u2009<\u20090.0001). Significant association was also found in C<\/jats:styled-content>aucasians (WMD<\/jats:styled-content>\u2009=\u20092.41; 95% CI<\/jats:styled-content> 1.18\u20133.64; P<\/jats:italic>\u2009=\u20090.0001). Subgroup analysis by gender indicated GG<\/jats:styled-content> genotype carriers had older age of ESRD<\/jats:styled-content> than T<\/jats:styled-content> allele carriers in males (WMD<\/jats:styled-content>\u2009=\u20094.51; 95% CI<\/jats:styled-content> 3.95\u20135.08; P<\/jats:italic>\u2009=\u20090.00001), but not in females.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>GG<\/jats:styled-content> genotype of the Glu298Asp variant slowed the ESRD<\/jats:styled-content> progression in ADPKD<\/jats:styled-content>, while a allele carriers of the 4b\/a variant increased the risk of ESRD<\/jats:styled-content>. Variants of eNOS<\/jats:styled-content><\/jats:italic> gene might play different roles in the ESRD<\/jats:styled-content> progression in ADPKD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12310","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T08:38:57Z","timestamp":1404463137000},"page":"630-637","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of endothelial nitric oxide synthase<\/i> gene on end stage renal disease progression in autosomal dominant polycystic kidney disease"],"prefix":"10.1111","volume":"19","author":[{"given":"Cheng","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Nephrology 252 Hospital of the Chinese People's Liberation Army Beijing China"},{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010chen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010liang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010gang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010lin","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.903923"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu044"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl412"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12045"},{"key":"e_1_2_5_6_1","first-page":"105","article-title":"Human evaluation of the Glu298Asp polymorphism in NOS3 gene and its relationship with onset age of ESRD in Iranian patients suffering from ADPKD","volume":"1","author":"Dasar N","year":"2012","journal-title":"Int. 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