{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:35:33Z","timestamp":1791218133477,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T00:00:00Z","timestamp":1413072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Taiwan Department of Health Clinical Trial and Research Center of Excellence","award":["DOH102-TD-B-111-004"],"award-info":[{"award-number":["DOH102-TD-B-111-004"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Fibroblast growth factor 23 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23) and <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho are associated with vascular calcification and cardiovascular disease in dialysis patients. Sevelamer has been shown to reduce progression of vascular calcification. This study aimed to determine the long\u2010term effect of sevelamer treatment on serum <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 and <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho levels in chronic haemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the post\u2010hoc analysis, we measured serum <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho and other biochemical factors (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, i\u2010<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>, hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) in 50 haemodialysis patients, who completed a 48\u2010week, open\u2010<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>abel, controlled randomized parallel\u2010group study. Twenty\u2010three patients received sevelamer and 27 patients received calcium carbonate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 48\u2010week sevelamer treatment, there were significant changes with lower <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (from 2.82\u2009\u00b1\u20090.78 to 1.65\u2009\u00b1\u20090.53\u2009mmol\/L, <jats:italic>P<\/jats:italic>\u2009=\u20090.000), lower <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 (from 2465.97 (2568.88) to 795.61 (1098.39), <jats:italic>P<\/jats:italic>\u2009=\u20090.000) and higher s\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho levels (from 189.35 (161.88) to 252.94 (517.80) pg\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). In calcium carbonate group, there were no significant changes of <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23, but with a borderline significant increase of s\u2010<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho level (from 142.34 (265.24) to 188.57 (252.38) pg\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.054). Multivariate analysis showed that <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 decrement was associated with sevelamer treatment (\u03b2\u2009=\u2009\u22120.277, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), change of serum phosphate (\u03b2\u2009=\u20090.609, <jats:italic>P<\/jats:italic>\u2009=\u20090.000) and calcium levels (\u03b2\u2009=\u20090.635, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). The increase of serum Klotho was associated with the decrease of serum phosphate (\u03b2\u2009=\u20090.490, <jats:italic>P<\/jats:italic>\u2009=\u20090.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maintenance <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients had lower serum <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 levels, accompanied with significantly increased serum <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho levels, after 48\u2010week sevelamer treatment. The <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>23 decrement was associated with sevelamer use, the change of serum phosphate and calcium levels. The serum <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>lotho increment was proportional to the phosphate\u2010lowering power of the binders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12319","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T04:53:31Z","timestamp":1407819211000},"page":"672-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Long\u2010term sevelamer treatment lowers serum fibroblast growth factor 23 accompanied with increasing serum <scp>K<\/scp>lotho levels in chronic haemodialysis patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Hsin\u2010Hung","family":"Lin","sequence":"first","affiliation":[{"name":"The Kidney Institute and Division of Nephrology China Medical University Hospital  Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Hsiang","family":"Liou","sequence":"additional","affiliation":[{"name":"Hsin\u2010Jen Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Shiou","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology National Taiwan University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Yuang","family":"Lin","sequence":"additional","affiliation":[{"name":"Children Medical Center China Medical University Hospital  Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu\u2010Ching","family":"Huang","sequence":"additional","affiliation":[{"name":"The Kidney Institute and Division of Nephrology China Medical University Hospital  Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science College of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.12.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.130"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr208"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.12.027"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010068"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080936"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706130"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-114397"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs460"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN107204"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121311"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00434.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05880809"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001994"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq053"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2005.00293.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05420709"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012030223"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319650"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.47"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121293"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0694"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1985"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.18388\/abp.2013_1970","article-title":"Serum soluble Klotho protein level is associated with residual diuresis in incident peritoneal dialysis patients","volume":"60","author":"Golembiewska E","year":"2013","journal-title":"Acta Biochim. 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