{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:15:17Z","timestamp":1778001317207,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) is one of the main causes of morbidity and mortality in cases of envenomation by venomous snakes. The present study was carried out to investigate the clinical and laboratory manifestations in accidents with venomous snakes and the risk factors associated with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> in these accidents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was carried out with patients victims of snakebite admitted to a reference centre. <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was defined according to the <jats:styled-content style=\"fixed-case\">RIFLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AKIN<\/jats:styled-content> criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 276 patients were included, of which 230 (83.7%) were males. <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was observed in 42 cases (15.2%). The mean genus involved in the accidents was <jats:italic>Bothrops<\/jats:italic> (82.2%). Mean age of patients with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> was higher than in patients without <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> (43\u2009\u00b1\u200920 vs. 34\u2009\u00b1\u200921 years, <jats:italic>P<\/jats:italic>\u2009=\u20090.015). The time elapsed between the accident and medical care was higher in the <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> group (25\u2009\u00b1\u200928 vs. 14\u2009\u00b1\u200916h, <jats:italic>P<\/jats:italic>\u2009=\u20090.034), as well as the time elapsed between the accident and the administration of antivenom (30.7\u2009\u00b1\u200927 vs. 15\u2009\u00b1\u200916\u2009h, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Haemodialysis was required in 30% of cases and complete renal function recovery was observed in 54.8% of cases at hospital discharge. There were four deaths, none of which had <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>. Factors associated with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> were haemorrhagic abnormalities (<jats:italic>P<\/jats:italic>\u2009=\u20090.036, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20096.718, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.067\u201325.661) and longer length of hospital stay (<jats:italic>P<\/jats:italic>\u2009=\u20090.004, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.165\u20132.088).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute kidney injury is an important complication of snakebite accidents, showing low mortality, but high morbidity, which can lead to partial renal function recovery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12327","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T04:23:58Z","timestamp":1408076638000},"page":"764-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Acute kidney injury after snakebite accident treated in a <scp>B<\/scp>razilian tertiary care centre"],"prefix":"10.1111","volume":"19","author":[{"given":"Polianna L. 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M.","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Toxicological Assistance Center Instituto Dr. Jos\u00e9 Frota  Fortaleza Cear\u00e1 Brazil"},{"name":"Post\u2010Graduation Program in Medical Sciences Department of Internal Medicine School of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldo B.","family":"Silva Junior","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Collective Health Health Sciences Center School of Medicine University of Fortaleza  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla N.","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Medical Sciences Department of Internal Medicine School of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianna B.","family":"Lima","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Medical Sciences Department of Internal Medicine School of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline B.","family":"Lima","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Medical Sciences Department of Internal Medicine School of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yago S.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Medical Sciences Department of Internal Medicine School of Medicine Federal University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Socorro B.","family":"Veras","sequence":"additional","affiliation":[{"name":"Toxicological Assistance Center Instituto Dr. Jos\u00e9 Frota  Fortaleza Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa M. 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