{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:27:04Z","timestamp":1773833224633,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Estimating fluid balance in haemodialysis patients is essential when determining dry weight, but limited methods are currently available. B<\/jats:styled-content>\u2010type natriuretic peptide (BNP)<\/jats:styled-content> is a useful surrogate marker in patients with congestive heart failure (CHF<\/jats:styled-content>), but whether its validity could be generalized to haemodialysis patients has not been studied well.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 457 haemodialysis patients at a dialysis centre were analyzed. Determinants of BNP<\/jats:styled-content> were assessed in connection with ultrasound cardiography (UCG<\/jats:styled-content>) records, K<\/jats:styled-content>t\/V<\/jats:styled-content>, ultrafiltration rate (UFR<\/jats:styled-content>), and demographic factors. All\u2010cause death and cardiovascular (CV<\/jats:styled-content>) events were recorded as the main outcome.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the UCG<\/jats:styled-content> records, left atrial diameter (LAD<\/jats:styled-content>), left ventricular ejection fraction (LVEF<\/jats:styled-content>), were determinants of log\u2010transformed (ln) BNP<\/jats:styled-content>; UFR<\/jats:styled-content>, age and sex were also significant. There was a positive correlation between BNP<\/jats:styled-content> and LAD<\/jats:styled-content> (r\u2009=\u20090.285, P<\/jats:italic>\u2009<\u20090.001). Receiver operating characteristic (ROC<\/jats:styled-content>) analysis revealed that BNP<\/jats:styled-content> had 90% and 80% sensitivity to predict the presence of LA<\/jats:styled-content> enlargement of 77.9\u2009pg\/mL and 133.2\u2009pg\/mL, respectively. Higher BNP<\/jats:styled-content> and lower LVEF<\/jats:styled-content> were associated with higher risk for developing all\u2010cause death and CVD<\/jats:styled-content>. In the adjusted model, patients with BNP<\/jats:styled-content> higher than 471\u2009pg\/mL had hazard ratio of 2.18 (95% confidence interval (CI<\/jats:styled-content>) 1.20\u20133.96, P<\/jats:italic>\u2009=\u20090.01), compared to those with BNP<\/jats:styled-content> <109\u2009pg\/mL.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>B<\/jats:styled-content>\u2010type natriuretic peptide was determined by LAD<\/jats:styled-content>, LVEF<\/jats:styled-content>, UFR<\/jats:styled-content>, age and sex. BNP<\/jats:styled-content> and LAD<\/jats:styled-content> had positive correlation and BNP<\/jats:styled-content> could become a useful tool for estimating the presence of LA<\/jats:styled-content> enlargement. BNP<\/jats:styled-content> and LVEF<\/jats:styled-content> was a strong risk factor for predicting all\u2010cause death and CV<\/jats:styled-content> events among patients undergoing haemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12329","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T08:59:51Z","timestamp":1408525191000},"page":"777-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic value of B<\/scp>\u2010type natriuretic peptide for estimating left atrial size and its usefulness for predicting all\u2010cause mortality and cardiovascular events among chronic haemodialysis patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Junichi","family":"Ishigami","sequence":"first","affiliation":[{"name":"Department of Nephrology Shuuwa General Hospital Saitama Japan"},{"name":"Department of Nephrology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Iimori","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shuuwa General Hospital Saitama Japan"},{"name":"Department of Nephrology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shuuwa General Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Itabashi Chuo General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2007.00148.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr678"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00099.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002745"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020233"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031681"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs365"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000054164.99881.00"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50118"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)00812-1"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Group KDIGOKCW","year":"2013","journal-title":"Kidney Int. 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