{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:30:30Z","timestamp":1768285830529,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of science and technology","award":["102-2314-B-010-004-MY3"],"award-info":[{"award-number":["102-2314-B-010-004-MY3"]}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V103C-024"],"award-info":[{"award-number":["V103C-024"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>The introduction of erythropoiesis\u2010stimulating agents (ESAs<\/jats:styled-content>) markedly improved the lives of many anaemic patients with chronic kidney disease (CKD<\/jats:styled-content>). In T<\/jats:styled-content>aiwan, the strategy of management of anaemia in patients with CKD<\/jats:styled-content> was different from many other parts of the world. In 1996, the National Health Insurance Administration of T<\/jats:styled-content>aiwan applied a more restrictive reimbursement criteria for ESA<\/jats:styled-content> use in patients with CKD<\/jats:styled-content>. ESA<\/jats:styled-content> is to be initiated when non\u2010dialysis CKD<\/jats:styled-content> patients have a serum creatinine >6\u2009mg\/dL and a hematocrit <28% to maintain a hematocrit level not exceeding 30%. The maximal dose of epoetin\u2010\u03b1 or \u03b2 was 20\u2009000\u2009U<\/jats:styled-content> per month. The target haemoglobin range and dose limitation for ESAs<\/jats:styled-content> were the same for dialysis CKD<\/jats:styled-content> patients. Thus, long before randomized controlled trials showing an increased risk for cardiovascular events at nearly normal haemoglobin concentrations and higher ESA<\/jats:styled-content> doses in CKD<\/jats:styled-content>, nephrologists in T<\/jats:styled-content>aiwan had avoided the use of disproportionately high dosages of ESAs<\/jats:styled-content> to achieve a haemoglobin level of 10\u201311\u2009g\/dL. Moreover, intravenous iron supplementation was encouraged earlier in T<\/jats:styled-content>aiwan in 1996, when we reached consensus on the diagnostic criteria for iron deficiency (serum ferritin <300\u2009ng\/mL and\/or transferrin saturation <30%). The experience of CKD<\/jats:styled-content> anaemia management in T<\/jats:styled-content>aiwan demonstrated that a reasonable haemoglobin target can be achieved by using the lowest possible ESA<\/jats:styled-content> dose and intravenous iron supplementation.<\/jats:p>","DOI":"10.1111\/nep.12332","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T03:59:10Z","timestamp":1409025550000},"page":"735-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anaemia management in patients with chronic kidney disease: T<\/scp>aiwan practice guidelines"],"prefix":"10.1111","volume":"19","author":[{"given":"Szu\u2010Chun","family":"Hung","sequence":"first","affiliation":[{"name":"Division of Nephrology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Buddhist Tzu Chi University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko\u2010Lin","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Nephrology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and Buddhist Tzu Chi University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Der\u2010Cherng","family":"Tarng","sequence":"additional","affiliation":[{"name":"Department and Institute of Physiology National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Nephrology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Gerontology Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai\u2010Szu","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology Taipei Medical University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung\u2010Po","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Wei Gong Memorial Hospital Miaoli Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198701083160203"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907203210305"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-12-992"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390903"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065485"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062276"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907845"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.03.011"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn406"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60952-6"},{"key":"e_1_2_3_12_1","unstructured":"United States Renal Data Systems (USRDS) 2012 annual data report."},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.03.023"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.382"},{"key":"e_1_2_3_15_1","unstructured":"FullerDS RobinsonBM BieberBet\u2009al.International comparisons illustrate effect of payment and regulatory changes on anemia practice in U.S. hemodialysis patients: The Dialysis Outcomes and Practice Patterns Study. American Society of Nephrology's Kidney Week2013."},{"key":"e_1_2_3_16_1","first-page":"S299","article-title":"KDIGO clinical practice guideline for anemia in chronic kidney disease","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group","year":"2012","journal-title":"Kidney Int. Suppl."},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168837"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000169091"},{"key":"e_1_2_3_19_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/089686089701700126","article-title":"Hyporesponsiveness to erythropoietin","volume":"17","author":"Tarng DC","year":"1997","journal-title":"Perit. Dial. Int."},{"key":"e_1_2_3_20_1","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1038\/sj.ki.4490858","article-title":"Erythropoietin hyporesponsiveness: From iron deficiency to iron overload","volume":"69","author":"Tarng DC","year":"1999","journal-title":"Kidney Int. Suppl."},{"issue":"2","key":"e_1_2_3_21_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ndt\/14.suppl_2.61","article-title":"European best practice guidelines for the management of anaemia in patients with chronic renal failure","volume":"14","author":"Cameron JS","year":"1999","journal-title":"Nephrol. Dial. Transplant."},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.03.010"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90151-5"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V113530"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.0320s1009.x"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000035250.66458.67"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050295"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040423"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph1018"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.09.004"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.179"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:11:51Z","timestamp":1696227111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/nep.12332"],"URL":"https:\/\/doi.org\/10.1111\/nep.12332","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]},"assertion":[{"value":"2014-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}