{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:12:56Z","timestamp":1783548776242,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004017","name":"The Japanese Association of Dialysis Physicians","doi-asserted-by":"crossref","award":["JADP Grant 2011-08"],"award-info":[{"award-number":["JADP Grant 2011-08"]}],"id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Malnutrition is highly prevalent in haemodialysis (HD<\/jats:styled-content>) patients, and it contributes to morbidity and mortality. Fibroblast growth factor\u201023 (FGF<\/jats:styled-content>\u201023) and K<\/jats:styled-content>lotho contribute to chronic kidney disease\u2010mineral and bone disorder (CKD\u2010MBD<\/jats:styled-content>) in HD<\/jats:styled-content> patients, but the role that these molecules play in determining nutritional status is currently unknown.<\/jats:p><\/jats:sec>Methods<\/jats:title>A cross\u2010sectional study examining 77 HD<\/jats:styled-content> patients was performed. The plasma concentrations of FGF<\/jats:styled-content>\u201023 and soluble K<\/jats:styled-content>lotho (s\u2010K<\/jats:styled-content>lotho) were studied to evaluate their association with muscle mass, which was investigated by abdominal muscle areas measured using computed tomography and by creatinine (C<\/jats:styled-content>r) production estimated using the C<\/jats:styled-content>r kinetic model.<\/jats:p><\/jats:sec>Results<\/jats:title>Plasma FGF<\/jats:styled-content>\u201023 concentrations were significantly and positively correlated with abdominal muscle areas and C<\/jats:styled-content>r production (rho<\/jats:italic>\u2009=\u20090.301, P<\/jats:italic>\u2009<\u20090.01 and rho<\/jats:italic>\u2009=\u20090.345, P<\/jats:italic>\u2009<\u20090.01, respectively). In contrast, s\u2010K<\/jats:styled-content>lotho was not significantly correlated with these muscle mass indices and plasma FGF<\/jats:styled-content>\u201023 concentrations. Multiple regression analyses showed that FGF<\/jats:styled-content>\u201023 was a significant independent predictor of both muscle mass indices (P<\/jats:italic>\u2009<\u20090.01 and P<\/jats:italic>\u2009<\u20090.05, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Plasma FGF<\/jats:styled-content>\u201023 concentrations were associated with muscle mass indices in HD<\/jats:styled-content> patients. Our findings suggest that FGF<\/jats:styled-content>\u201023 and nutritional status are linked and this link is most likely independent of s\u2010K<\/jats:styled-content>lotho.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12333","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T23:25:41Z","timestamp":1409873141000},"page":"784-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Plasma levels of fibroblast growth factor\u201023 are associated with muscle mass in haemodialysis patients"],"prefix":"10.1111","volume":"19","author":[{"given":"Hirotaka","family":"Fukasawa","sequence":"first","affiliation":[{"name":"Renal Division Department of Internal Medicine Iwata City Hospital Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Renal Division Department of Internal Medicine Iwata City Hospital Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kinoshita\u2010Katahashi","sequence":"additional","affiliation":[{"name":"Renal Division Department of Internal Medicine Iwata City Hospital Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Niwa","sequence":"additional","affiliation":[{"name":"Renal Division Department of Internal Medicine Iwata City Hospital Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Yasuda","sequence":"additional","affiliation":[{"name":"First Department of Medicine Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"The Department of Clinical Nutrition School of Food and Nutritional Sciences University of Shizuoka Shizuoka Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Furuya","sequence":"additional","affiliation":[{"name":"Renal Division Department of Internal Medicine Iwata City Hospital Iwata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002585"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00422.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/35.5.1192"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.442"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1997.tb00246.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.116"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301264"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121293"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/36285"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05315"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419081"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121311"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2240"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114245"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.826"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.844506"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46122"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056695"},{"key":"e_1_2_7_20_1","first-page":"S17","article-title":"KDOQI clinical practice guidelines for nutrition in chronic renal failure","volume":"35","author":"Foundation NK","year":"2000","journal-title":"Am. 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