{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:35:45Z","timestamp":1790717745394,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This pilot study assesses the safety and feasibility of autologous mesenchymal stromal cell (\n                      <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                      ) transplantation in four patients that underwent living donor renal transplantation, and the effect on the immunophenotype and functionality of peripheral\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      lymphocytes following transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All patients received low dose\n                      <jats:styled-content style=\"fixed-case\">ATG<\/jats:styled-content>\n                      induction followed by calcineurin inhibitor\u2010based triple drug maintenance immunosuppression. Autologous\n                      <jats:styled-content style=\"fixed-case\">MSCs<\/jats:styled-content>\n                      were administered intravenously pre transplant and day 30 post\u2010transplant. Patients were followed up for 6 months. The frequency of regulatory\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      cells and\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      cell proliferation was assessed at different time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      None of the four patients developed any immediate or delayed adverse effects following\n                      <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                      infusion. All had excellent graft function, and none developed graft dysfunction. Protocol biopsies at 1 and 3 months did not reveal any abnormality. Compared to baseline, there was an increase in the\n                      <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>\n                      \u2009+\u2009\n                      <jats:styled-content style=\"fixed-case\">CD25<\/jats:styled-content>\n                      +\n                      <jats:styled-content style=\"fixed-case\">FOXP3<\/jats:styled-content>\n                      + regulatory\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      cells and reduction in\n                      <jats:styled-content style=\"fixed-case\">CD4 T<\/jats:styled-content>\n                      cell proliferation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We conclude that autologous\n                      <jats:styled-content style=\"fixed-case\">MSCs<\/jats:styled-content>\n                      can be used safely in patients undergoing living donor renal transplantation, lead to expansion of regulatory\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      cells and decrease in\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      cell proliferation. Larger randomized trials studies are needed to confirm these findings and evaluate whether this will have any impact on immunosuppressive therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.12338","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T03:40:48Z","timestamp":1410925248000},"page":"25-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Safety and efficacy of autologous mesenchymal stromal cells transplantation in patients undergoing living donor kidney transplantation: A pilot study"],"prefix":"10.1111","volume":"20","author":[{"given":"Chetan","family":"Mudrabettu","sequence":"first","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Rakha","sequence":"additional","affiliation":[{"name":"Department of Translational and Regenerative Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok K","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepesh B","family":"Kanwar","sequence":"additional","affiliation":[{"name":"Department of Renal Transplant Surgery Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukut","family":"Minz","sequence":"additional","affiliation":[{"name":"Department of Renal Transplant Surgery Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Sakhuja","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Marwaha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivekanand","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education and Research  Chandigarh India"},{"name":"Department of Translational and Regenerative Medicine Postgraduate Institute of Medical Education and Research  Chandigarh India"},{"name":"George Institute for Global Health  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Brenner's and Rector's The Kidney","author":"Taal MW","year":"2012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00515.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07493-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20602.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01268.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b4425a"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ea4240"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04950610"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.316"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705798"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060772"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01758-10"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067812"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.6.3933"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.6370"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04115.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182754c53"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2011.623691"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"1408e14","DOI":"10.1038\/leu.2011.108","article-title":"Mesenchymal stromal cell \u2018licensing\u2019: A multi\u2010 step process","volume":"25","author":"Krampera M","year":"2011","journal-title":"Leukemia"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524011313050016"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.01.004"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240802684194"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2560"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.445"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2011.08.009"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12109"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12338","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T05:39:20Z","timestamp":1696138760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,23]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/nep.12338"],"URL":"https:\/\/doi.org\/10.1111\/nep.12338","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,23]]},"assertion":[{"value":"2014-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}