{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:09:21Z","timestamp":1759565361948,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T00:00:00Z","timestamp":1422057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MOP130483"],"award-info":[{"award-number":["MOP130483"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The kidney is an organ highly susceptible to injury by regional tissue oxygen desaturation during hypoxic episodes. Transcutaneous monitoring of renal tissue oxygen saturation is therefore of increasing interest. The aim of the present study was to compare renal tissue oxygen saturation measured by near\u2010infrared spectroscopy (<jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content>) during acute hypoxia in neonates directly on the kidney and transcutaneously. We hypothesized that transcutaneous renal tissue oxygen saturation measurements would be influenced by superficial tissue. Five term newborn piglets were anesthetized, instrumented and exposed to normocapnic hypoxia at an inspired oxygen concentration of 0.14. Regional tissue oxygen saturation (<jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>) was simultaneously measured for comparison with the sensor of <jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content> (Invos 5100, Somanetics Corp., Troy, MI, USA) applied directly on the left kidney (<jats:sub>renaldirect<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>) and on the skin of right flank above the right kidney (<jats:sub>renalskin<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>). Cerebral regional tissue oxygenation (<jats:sub>cerebralskin<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>), arterial oxygen saturation, heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) and mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) were also monitored. <jats:styled-content style=\"fixed-case\">NIRS<\/jats:styled-content> parameters were analyzed in 5\u2009s intervals during first 2\u2009min of hypoxia. Hypoxia was achieved with an arterial oxygen desaturation from median (range) 95.3% (86.8\u201398.0) to 23.5% (13.0\u201341.0) after 2\u2009min. <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> did not change significantly during hypoxia. There were pronounced and lower <jats:sub>renaldirect<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> readings when compared with those of <jats:sub>renalskin<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> with significant differences from 25 to 55\u2009s after initiation of hypoxia. Changes of <jats:sub>cerebralskin<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> and <jats:sub>renalskin<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:roman>rSO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> were similar. Transcutaneous monitoring of renal tissue oxygen saturation may underestimate acute oxygen desaturation of the kidney during hypoxia in neonates.<\/jats:p>","DOI":"10.1111\/nep.12357","type":"journal-article","created":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T08:41:46Z","timestamp":1422088906000},"page":"107-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Is renal tissue oxygen desaturation during severe hypoxia underestimated? An observational study in term newborn piglets"],"prefix":"10.1111","volume":"20","author":[{"given":"Gerhard","family":"Pichler","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Centre for the Studies of Asphyxia and Resuscitation Neonatal Research Unit Royal Alexandra Hospital  Edmonton Alberta Canada"},{"name":"Department of Pediatrics Medical University of Graz  Graz Austria"},{"name":"Research Unit for Neonatal Micro\u2010 and Macrocirculation Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Yin","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Centre for the Studies of Asphyxia and Resuscitation Neonatal Research Unit Royal Alexandra Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Tze\u2010Fun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Centre for the Studies of Asphyxia and Resuscitation Neonatal Research Unit Royal Alexandra Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott S","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Centre for the Studies of Asphyxia and Resuscitation Neonatal Research Unit Royal Alexandra Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg M","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Centre for the Studies of Asphyxia and Resuscitation Neonatal Research Unit Royal Alexandra Hospital  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1541-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.033"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000235248.70482.14"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.161604"},{"issue":"1","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/cs1010021","article-title":"Adipose tissue thickness affects in vivo quantitative near\u2010IR spectroscopy in human skeletal muscle","volume":"101","author":"Beekvelt MC","year":"2001","journal-title":"Clin. Sci. (Lond.)"},{"key":"e_1_2_9_8_1","first-page":"e3166","article-title":"A swine model of neonatal asphyxia","volume":"56","author":"Cheung P\u2010Y","year":"2011","journal-title":"J. Vis. 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