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Patients receiving dialysis for \u22653 months and who are aged \u226550 years, or who are \u226518 years and have diabetes or cardiovascular disease, were eligible. The primary outcome was the proportion of participants who complete a 6\u2010week run\u2010in phase in which all participants received carvedilol titrated from 3.125\u2009mg twice daily to 6.25\u2009mg twice daily. Other measures included how many patients are screened, the proportion recruited, the overall recruitment rate, the proportion of participants who remain on study drug for 12 months and the incidence of intra\u2010dialytic hypotension while on randomized treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">BLOCADE F<\/jats:styled-content>\n                      easibility\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      tudy commenced recruiting in\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      ay 2011 and involves 11 sites in\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      ustralia and\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                      ew\n                      <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>\n                      ealand.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">BLOCADE F<\/jats:styled-content>\n                      easibility\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      tudy will inform the design of a larger clinical endpoint study to determine whether beta\u2010blocking agents provide benefit to patients receiving dialysis, and define whether such a study is feasible.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.12362","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T05:39:34Z","timestamp":1415597974000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The rationale and design of the\n                    <scp>B<\/scp>\n                    eta\u2010blocker to\n                    <scp>LO<\/scp>\n                    wer\n                    <scp>CA<\/scp>\n                    rdiovascular\n                    <scp>D<\/scp>\n                    ialysis\n                    <scp>E<\/scp>\n                    vents (\n                    <scp>BLOCADE<\/scp>\n                    )\n                    <scp>F<\/scp>\n                    easibility\n                    <scp>S<\/scp>\n                    tudy"],"prefix":"10.1111","volume":"20","author":[{"given":"Matthew 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