{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:19:26Z","timestamp":1762917566356,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["571045"],"award-info":[{"award-number":["571045"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Observational reports suggest extended dialysis hours are associated with improved outcomes. These findings are confounded by better prognostic characteristics among people practising extended hours. The aim of this article is to provide an overview of the methods and baseline characteristics for <jats:styled-content style=\"fixed-case\">ACTIVE D<\/jats:styled-content>ialysis <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre, randomized, open\u2010label, blinded endpoint\u2010assessment trial randomized participants receiving maintenance haemodialysis therapy to either extended (\u226524\u2009h) or standard (12\u201318\u2009h) weekly haemodialysis for 12 months. A web\u2010based randomization system used minimization to ensure balanced allocation across regions, dialysis setting and dialysis vintage. The primary outcome is the change in quality of life over 12 months of study treatment assessed by <jats:styled-content style=\"fixed-case\">EQ\u20105D<\/jats:styled-content>. Secondary outcomes include change in left ventricular mass index assessed by magnetic resonance imaging and safety outcomes including dialysis access events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 200 participants were recruited between 2009 and 2013 from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia (29.0%), <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina (62.0%), <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anada (5.5%) and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand (3.5%). Participants had a mean age of 52 (\u00b1\u200912) years and 11.5% were dialysing at home, with a mean duration of 13.9\u2009h per week over a median of three sessions. At baseline, 32.5% had a history of cardiovascular disease and 36.5% had diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ACTIVE D<\/jats:styled-content>ialysis <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy has met its planned recruitment target. The participant population are drawn from a range of health service settings in a global context. The study will contribute important evidence on the benefits and harms of extending weekly dialysis hours. The trial is registered at clinicaltrials.gov (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>00649298).<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12385","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T10:01:49Z","timestamp":1419242509000},"page":"257-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Design and participant baseline characteristics of \u2018A <scp>C<\/scp>linical <scp>T<\/scp>rial of <scp>IntensiVE D<\/scp>ialysis\u2019: The <scp>ACTIVE D<\/scp>ialysis <scp>S<\/scp>tudy"],"prefix":"10.1111","volume":"20","author":[{"given":"Meg J","family":"Jardine","sequence":"first","affiliation":[{"name":"The George Institute for Global Health  Sydney New South Wales Australia"},{"name":"Renal Unit Concord Repatriation General Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LI","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A","family":"Gray","sequence":"additional","affiliation":[{"name":"Renal Medicine Nambour General Hospital  Nambour Queensland Australia"},{"name":"Sunshine Coast Clinical School The University of Queensland  Nambour Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janak","family":"de Zoysa","sequence":"additional","affiliation":[{"name":"Renal Services North Shore Hospital  Auckland New Zealand"},{"name":"Department of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Medicine University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin P","family":"Gallagher","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Sydney New South Wales Australia"},{"name":"Concord Clinical School Sydney Medical School  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Howard","sequence":"additional","affiliation":[{"name":"School of Public Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Hertier","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventative Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Cass","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Sydney New South Wales Australia"},{"name":"Menzies School of Health Research Charles Darwin University  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlado","family":"Perkovic","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Sydney New South Wales Australia"},{"name":"Department of Renal Medicine Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"ACTIVE Dialysis Steering Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"volume-title":"Annual Data Report: Atlas of Chronic Kidney Disease and End\u2010Stage Renal Disease in the United States","year":"2013","author":"U.S. Renal Data System. 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