{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:19:00Z","timestamp":1760955540084},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum creatinine is routinely used to monitor renal function in transplant recipients. External factors including diet, exercise and hydration status can also influence serum creatinine concentration on a day\u2010to\u2010day basis. We describe a case of a patient whose serum creatinine increased from 128 to 171\u2009\u03bcmol\/L after ingestion of creatinine\u2010rich (3098\u2009\u03bcmol\/L) soup. A renal biopsy was performed but revealed no cause for the rise in creatinine and by the next day, serum creatinine had returned to baseline. We conducted two experiments to examine the effect of soup ingestion by healthy volunteers. We measured the creatinine concentration of various store\u2010bought stock preparations and found creatinine concentrations less than one\u2010quarter of that contained in our patient's homemade soup. A creatinine\u2010rich soup (4334\u2009\u03bcmol\/L) was ingested by six healthy volunteers age 33 (\u00b1\u20096.5) years with baseline normal serum creatinine 68 (\u00b1\u200914) \u03bcmol\/L. Mean (standard deviation) serum creatinine increased to 77 (\u00b1\u200911) \u03bcmol\/L 4 hours after soup ingestion (<jats:italic>P<\/jats:italic>\u2009=\u20090.0015, paired <jats:italic>t<\/jats:italic>\u2010test). Mean (standard deviation) creatinine clearance, extrapolated from the 4 hour urine collection following soup ingestion, was high (267\u2009\u00b1\u2009198\u2009mL\/min) exhibiting a supra\u2010normal creatinine clearance. The rate of serum creatinine rise was lower in volunteers compared with the transplant patient, consistent with the concept of renal functional reserve. Our case highlights the importance of taking dietary changes into account when interpreting serum creatinine as a measure of allograft function.<\/jats:p>","DOI":"10.1111\/nep.12391","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T08:13:47Z","timestamp":1427271227000},"page":"297-299","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dangers of broth after transplantation"],"prefix":"10.1111","volume":"20","author":[{"given":"Shikha","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Renal Medicine and Transplantation Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Sukkar","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine and Transplantation Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Wynter","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine and Transplantation Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine and Transplantation Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine and Transplantation Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve J","family":"Chadban","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine and Transplantation Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Central Clinical School Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01559.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.10.017"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6170.1049"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412293312618"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90399-X"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.53"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1770"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214234"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12391","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:37:15Z","timestamp":1696286235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/nep.12391"],"URL":"https:\/\/doi.org\/10.1111\/nep.12391","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]},"assertion":[{"value":"2015-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}