{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:17:57Z","timestamp":1761059877758},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Coagulation abnormalities, endothelial dysfunction and arteriosclerosis play a key role in cardiovascular disease state observed in transplanted patients. Plasma adiponectin levels are lower following kidney transplantation. However, there is still a debate about this topic in the literature. This study evaluated, adiponectin levels associated with markers of endothelial dysfunction and platelet function in renal transplant patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010six renal transplant patients were studied. Patients were grouped according to immunosuppression regimen. Group 1 (<jats:italic>n\u2009=<\/jats:italic>\u200936) were treated with cyclosporine A based regimes and group 2 (<jats:italic>n\u2009=<\/jats:italic>\u200930) were treated with tacrolimus based regimes. Plasma adiponectin, asymmetric dimethyl arginine (<jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content>), s<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010selectin levels and platelet aggregation tests were studied and were compared with those in control group (<jats:italic>n\u2009=<\/jats:italic>\u200915, group 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adiponectin, sP\u2010selectin and <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> levels were higher in group 1 and statistically significant differences were observed compared with those of group 2 and group 3, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Platelet aggregation values induced by agonists were lower in group 1 than group 2 and group 3, but the difference did not reach statistical significance (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adiponectin levels are elevated in line with <jats:styled-content style=\"fixed-case\">ADMA<\/jats:styled-content> and s<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u2010selectin levels. Since <jats:styled-content style=\"fixed-case\">CsA<\/jats:styled-content> induces higher adiponectin levels, platelet activation and endothelial dysfunction. These changes may be responsible for the increased risk of post\u2010transplant cardiovascular events in renal transplant patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12413","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T09:24:11Z","timestamp":1422955451000},"page":"392-398","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"Garip","family":"Sahin","sequence":"first","affiliation":[{"name":"Nephrology Department Eskisehir Osmangazi University Medical School  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Meltem","family":"Akay","sequence":"additional","affiliation":[{"name":"Hematology Department Eskisehir Osmangazi University Medical School  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"Uslu","sequence":"additional","affiliation":[{"name":"Biochemistry Department Eskisehir Osmangazi University Medical School  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cengiz","family":"Bal","sequence":"additional","affiliation":[{"name":"Biostatistics Department Eskisehir Osmangazi University Medical School  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Ugur","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Nephrology Department Eskisehir Osmangazi University Medical School  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer","family":"Gulbas","sequence":"additional","affiliation":[{"name":"Hematology Department Eskisehir Osmangazi University Medical School  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2007.03.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70239-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590410031715"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132490"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00600.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.25.2473"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.2.191"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000183750.22675.be"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.08.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2008.00921.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021883"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1161\/01.CIR.84.5.1984","article-title":"Endothelial dysfunction of the coranary microvasculature is associated with impaired coronary blood flow regulation in patients with early atherosclerosis","volume":"84","author":"Zeiher AM","year":"1991","journal-title":"Circulation"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00637.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.9.2032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307878200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251647.72673.c7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220802599163"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91610-1"},{"key":"e_1_2_7_20_1","first-page":"55","article-title":"Effects of immunosuppressive drugs platelet aggregation in vivo","volume":"7","author":"Malyszko J","year":"2002","journal-title":"Ann. 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