{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:22:40Z","timestamp":1791958960274,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A middle\u2010aged man received a kidney transplant from a deceased multi\u2010organ donor. The recipient suffered cardiac arrest several days post\u2010operatively and sustained hypoxic brain injury and was declared brain dead. Following the family's consent, the allograft kidney was retrieved and re\u2010transplanted into a man with end\u2010stage renal failure secondary to reflux nephropathy. The liver was not transplanted due to suspicion of fatty changes based on macroscopic appearance. After transplantation of other organs, liver histology revealed coagulative parenchymal necrosis with nuclear inclusions and moderate parenchymal cholestasis, suggestive of herpes viral hepatitis. Renal implantation biopsy showed histiocytes with enlarged nuclei containing viral inclusions in the capsular fibrous tissue, with positive immunostaining for herpes simplex virus (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>). Anti\u2010viral therapy was commenced immediately after obtaining histological evidence of donor <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> infection. Our recipient had pre\u2010formed immunoglobulin G antibodies to <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20102, and was immunoglobulin M negative pre\u2010transplant. <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> viraemia was detected day 5 post\u2010transplant with a viral load of 7688\u2009copies\/mL by polymerase chain reaction assay. The recipient completed a 30 day course of intravenous ganciclovir before switching to oral valganciclovir as standard cytomegalovirus prophylaxis. The <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> polymerase chain reaction became undetectable on day 7 of intravenous ganciclovir and has remained undetectable. The patient remains well 9 months post\u2010transplant with an estimated glomerular filtration rate of 61\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup>. Although renal allograft re\u2010use has been shown to be technically possible with a good outcome in this recipient, this does raise issues including assessment of allografts that have undergone repeated severe ischaemic insults and the potential of transmission of infections.<\/jats:p>","DOI":"10.1111\/nep.12423","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T20:56:10Z","timestamp":1427230570000},"page":"17-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Renal allograft re\u2010use and herpetic re\u2010infection"],"prefix":"10.1111","volume":"20","author":[{"given":"Stella","family":"Setyapranata","sequence":"first","affiliation":[{"name":"Department of Nephrology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Holt","sequence":"additional","affiliation":[{"name":"Department of Nephrology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate J","family":"Wiggins","sequence":"additional","affiliation":[{"name":"Department of Nephrology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Mulley","sequence":"additional","affiliation":[{"name":"Department of Nephrology Monash Medical Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Nephrology Monash Medical Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Landgren","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon P","family":"Eisen","sequence":"additional","affiliation":[{"name":"Victorian Infectious Diseases Service Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Young","sequence":"additional","affiliation":[{"name":"Donate Life Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Opdam","sequence":"additional","affiliation":[{"name":"Donate Life Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Nephrology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashayar","family":"Asadi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Austin Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Nephrology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ejcts.2008.06.026","article-title":"Heart allograft transplanted twice","volume":"34","author":"Simsir SA","year":"2008","journal-title":"Eur. 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