{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:11Z","timestamp":1787015711460,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n Calcineurin inhibitors reduce the acute rejection rate and greatly improve renal allograft survival. However, they are associated with some adverse events, including nephrotoxicity, a risk factor for allograft failure. Chronic calcineurin inhibitor\u2010induced nephrotoxicity causes irreversible damage to renal components, such as arteriolar hyaline thickening. The aim of this study is to investigate the risk factors for tacrolimus\u2010induced chronic nephrotoxicity using zero\u2010time biopsy specimens.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Between\n J<\/jats:styled-content>\n anuary 2001 and\n D<\/jats:styled-content>\n ecember 2010, 483 patients who underwent living\u2010related kidney transplantation and had also been placed on a tacrolimus\u2010based regimen were enrolled in this study. There were 1859 specimens evaluated comprising 483 zero\u2010time biopsy specimens and 1376 protocol and for\u2010cause biopsy specimens.\n \n D<\/jats:styled-content>\n e novo\n <\/jats:italic>\n arteriolar hyaline thickening due to tacrolimus\u2010induced chronic nephrotoxicity was scored according to the Banff classification aah score. In this study, tacrolimus\u2010induced nephrotoxicity was defined as a positive aah score.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 483 patients, 108 patients (22.4%) had biopsy\u2010proven tacrolimus\u2010induced chronic nephrotoxicity. Multivariate analysis showed that interlobular arteriosclerosis proven by zero\u2010time biopsy (\n OR<\/jats:styled-content>\n : 2.23, 95%\n CI<\/jats:styled-content>\n : 1.38\u20133.58,\n P<\/jats:italic>\n \u2009<\u20090.01) and acute rejection episodes (\n OR<\/jats:styled-content>\n : 1.58, 95%\n CI<\/jats:styled-content>\n : 1.00\u20132.47,\n P<\/jats:italic>\n \u2009=\u20090.04) were independent risk factors for tacrolimus\u2010induced chronic nephrotoxicity. However, tacrolimus\u2010induced chronic nephrotoxicity did not affect long\u2010term graft survival.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This is the first report showing that arteriosclerosis in zero\u2010time biopsy specimens is a risk factor for histological tacrolimus\u2010induced chronic nephrotoxicity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nep.12461","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T19:42:53Z","timestamp":1433274173000},"page":"51-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Arteriosclerosis in zero\u2010time biopsy is a risk factor for tacrolimus\u2010induced chronic nephrotoxicity"],"prefix":"10.1111","volume":"20","author":[{"given":"Takafumi","family":"Yagisawa","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Omoto","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Women's Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.01.038"},{"key":"e_1_2_6_3_1","first-page":"2585","article-title":"Prevalence of cyclosporine\u2010associated arteriolopathy in renal transplant biopsies from 1981 to 1992","volume":"26","author":"Str\u00f8m EH","year":"1994","journal-title":"Transplant. 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