{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:10:45Z","timestamp":1790835045092,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Polyomavirus <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> nephropathy (<jats:styled-content style=\"fixed-case\">BKVN<\/jats:styled-content>) is an important complication in kidney transplantation. After immunosuppressive agents are reduced, some patients experience a temporal increase in serum creatinine (<jats:styled-content style=\"fixed-case\">sCr<\/jats:styled-content>) before viral clearance. The histological characteristics of re\u2010biopsies were therefore investigated to evaluate the time course of remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">sCr<\/jats:styled-content> was measured and urinary cytology evaluated periodically in 14 patients with biopsy\u2010proven <jats:styled-content style=\"fixed-case\">BKVN<\/jats:styled-content>. Remission of <jats:styled-content style=\"fixed-case\">BKVN<\/jats:styled-content> was defined as re\u2010biopsies negative for <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40 large T antigen (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40\u2010<jats:styled-content style=\"fixed-case\">TAg<\/jats:styled-content>) or for decoy cells on at least three consecutive cytology tests. Early changes in <jats:styled-content style=\"fixed-case\">sCr<\/jats:styled-content> were correlated with re\u2010biopsy findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:styled-content style=\"fixed-case\">sCr<\/jats:styled-content> was 1.6\u2009\u00b1\u20090.6\u2009mg\/dL at diagnosis, increasing during the first 2 months to 2.6\u2009\u00b1\u20092.0\u2009mg\/dL, and decreasing thereafter, to 2.3\u2009\u00b1\u20091.2\u2009mg\/dL at 3\u20134 months. Two patients who experienced further increases in <jats:styled-content style=\"fixed-case\">sCr<\/jats:styled-content> at 3 months showed early graft loss, while the others showed clinical or histological remission. Nineteen re\u2010biopsies were obtained from eight patients over 4 months. Banff i\u2010scores were higher in re\u2010biopsies obtained during the first 2 months than the index biopsies and re\u2010biopsies at 2\u20134 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40\u2010<jats:styled-content style=\"fixed-case\">TAg<\/jats:styled-content> positivity was common in re\u2010biopsies during the first 2 months (10\/11 biopsies), but rarer at 2\u20134 months (2\/8 biopsies, <jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Temporal graft dysfunction and increased inflammation, called immune reconstitution, were observed at 2 months. Later <jats:styled-content style=\"fixed-case\">sCr<\/jats:styled-content> reversal is associated with remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12462","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T23:42:53Z","timestamp":1433288573000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation during the first two months in resolving polyomavirus <scp>BK<\/scp> nephropathy"],"prefix":"10.1111","volume":"20","author":[{"given":"Kosuke","family":"Masutani","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Tsuchimoto","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Matsukuma","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Nishiki","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehisa","family":"Kitada","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tsuruya","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Kyushu University  Fukuoka Japan"},{"name":"Integrated Therapy for Chronic Kidney Disease Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90608-8"},{"issue":"3","key":"e_1_2_6_3_1","first-page":"S19","article-title":"Improving Global Outcomes (KDIGO) Transplant Working Group. 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