{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:23:10Z","timestamp":1759479790439},"reference-count":13,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of probable <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>4d\u2010negative accelerated acute antibody\u2010mediated rejection due to non\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies. A 44 year\u2010old male was admitted to our hospital for a kidney transplant. The donor, his wife, was an <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> minor mismatch (blood type O to A) and had <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>itelman syndrome. Graft function was delayed; his serum creatinine level was 10.1\u2009mg\/d<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> at 3 days after transplantation. Open biopsy was performed immediately; no venous thrombosis was observed during surgery. Histology revealed moderate peritubular capillaritis and mild glomerulitis without <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>4d immunoreactivity. Flow cytometric crossmatching was positive, but no panel\u2010reactive antibodies against <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> or donor\u2010specific antibodies (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>bs) to major histocompatibility complex class <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\u2010related chain A (<jats:styled-content style=\"fixed-case\">MICA<\/jats:styled-content>) were detected. Taken together, we diagnosed him with probable <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>4d\u2010negative accelerated antibody\u2010mediated rejection due to non\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>, non\u2010<jats:styled-content style=\"fixed-case\">MICA<\/jats:styled-content> antibodies, the patient was treated with steroid pulse therapy (methylprednisolone 500\u2009mg\/day for 3 days), plasma exchange, intravenous immunoglobulin (40\u2009g\/body), and rituximab (200\u2009mg\/body) were performed. Biopsy at 58 days after transplantation, at which time <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>r levels were 1.56\u2009mg\/d<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>, found no evidence of rejection. This case, presented with a review of relevant literature, demonstrates that probable <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>4d\u2010negative accelerated acute <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> can result from non\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies.<\/jats:p>","DOI":"10.1111\/nep.12467","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T23:42:53Z","timestamp":1433288573000},"page":"75-78","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Probable <scp>C<\/scp>4d\u2010negative accelerated acute antibody\u2010mediated rejection due to non\u2010<scp>HLA<\/scp> antibodies"],"prefix":"10.1111","volume":"20","author":[{"given":"Takahito","family":"Niikura","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Nakada","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahoko","family":"Kamejima","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Furuya","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Mafune","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Internal Medicine The Jikei University School of Medicine  Tokyo 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