{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:30:43Z","timestamp":1768692643502,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathological classification of rejection in renal allografts (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>anff classification) has undergone substantial evolution for more than 20 years, and has been the diagnostic gold standard in clinical practice. The 2013 updated <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>anff classification encompasses a revised scheme of antibody\u2010mediated rejection (<jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content>) that consists of donor\u2010specific antibody (<jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>) positivity, characteristic histological manifestations for both acute and chronic <jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\u2010induced endothelial cell injury which is represented by either <jats:styled-content style=\"fixed-case\">C4d<\/jats:styled-content> positivity, microvascular inflammation or expression of activated endothelial gene transcripts. Other modified criteria include a <jats:styled-content style=\"fixed-case\">C4d<\/jats:styled-content> positivity threshold, and histological definition of transplant glomerulitis and transplant glomerulopathy. Morphologically, glomerulonephritis, either recurrent or <jats:italic>de novo,<\/jats:italic> can be challenging to differentiate from <jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content>\u2010mediated transplant glomerulitis. Endothelial arteritis by itself does not warrant the diagnosis of acute T\u2010cell mediated rejection; <jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content> should also be considered based on the <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content> test results. With regard to polyomavirus <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>\u2010associated nephropathy, immunohistochemical examination using anti\u2010simian virus (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>) 40 antibody can be a promising method to assess the quantitative viral load of polyomavirus <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> and graft survival. In summary, the 2013 updated <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>anff classification strictly defines <jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content> with histopathological and serological criteria irrespective of <jats:styled-content style=\"fixed-case\">C4d<\/jats:styled-content> positivity. Inclusion of gene expression data relevant to <jats:styled-content style=\"fixed-case\">ABMR<\/jats:styled-content> highlights that the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>anff criteria have entered the era of \u2018Seeing the Unseen\u2019 schemes, reflecting recent advances in understanding the molecular events in allograft injury.<\/jats:p>","DOI":"10.1111\/nep.12474","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T23:42:53Z","timestamp":1433288573000},"page":"2-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<scp>B<\/scp>anff 2013 update: Pearls and pitfalls in transplant renal pathology"],"prefix":"10.1111","volume":"20","author":[{"given":"Shigeo","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12590"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01688.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02761.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02813.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02159.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.168"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.61"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00921.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.02.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01473.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00299.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03261.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01995.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03647.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03757.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.212"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.10.026"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2013.09.004"},{"key":"e_1_2_9_20_1","first-page":"739","volume-title":"Heptinstall's Pathology of the Kidney","author":"Laszik Z","year":"2013"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000074"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03156.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02987.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2012.01673.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03926.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12079"},{"key":"e_1_2_9_27_1","article-title":"Isolated endarteritis and kidney transplant survival: a multicenter collaborative study","author":"Sis B","year":"2014","journal-title":"J. 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