{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:59:13Z","timestamp":1773737953857,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Idiopathic membranous nephropathy (IMN<\/jats:styled-content>), the commonest cause of adult nephrotic syndrome (NS<\/jats:styled-content>), accounts for only a minority of paediatric NS<\/jats:styled-content>. Antibodies to m\u2010type phospholipase A2<\/jats:styled-content> receptor (PLA2R<\/jats:styled-content>) are seen in two\u2010thirds of adult IMN<\/jats:styled-content> cases. PLA2R<\/jats:styled-content> staining in glomerular deposits is observed in 74% and 45% of adult and paediatric IMN<\/jats:styled-content> cases, respectively. However, there are no reports of anti\u2010PLA2R<\/jats:styled-content> in paediatric IMN<\/jats:styled-content>. We evaluated anti\u2010PLA2R<\/jats:styled-content> levels and PLA2R<\/jats:styled-content> in gloemrular deposits in paediatric IMN<\/jats:styled-content> seen at our center. Five cases were enrolled, all the cases stained for PLA2R<\/jats:styled-content> in glomeruli and three (60%) had antibodies to PLA2R<\/jats:styled-content> antigen. There was a parellel reduction in proteinuria and anti\u2010PLA2R<\/jats:styled-content> titer. The present report suggests that PLA2R<\/jats:styled-content> has a contributory role in the pathogenesis of paediatric IMN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/nep.12478","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T09:12:31Z","timestamp":1437469951000},"page":"572-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Antibodies to m\u2010type phospholipase A2<\/scp> receptor in children with idiopathic membranous nephropathy"],"prefix":"10.1111","volume":"20","author":[{"given":"Vinod","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritambhra","family":"Nada","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Suri","sequence":"additional","affiliation":[{"name":"Department of Paediatric Allergy and Immunology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Paediatric Allergy and Immunology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harbir Singh","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan Lal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivekanand","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Nephrology Postgraduate Institute of Medical Education & Research Chandigarh India"},{"name":"George Institute for Global Health New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)91905-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1978.23"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810457"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1011678"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012895"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.09.009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2574-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1681\/ASN.V93444","article-title":"etal. A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy","volume":"9","author":"Ponticelli C","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020166"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181ca3a7d"},{"key":"e_1_2_6_12_1","first-page":"750A","article-title":"Association of PLA2R and HLA\u2010DQA1 genetic variants with serum anti PLA2R antibody and clinical OUTCOME in Indian patients with idiopathic membranous nephropathy (Abstract)","volume":"25","author":"Sharma V","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_6_13_1","unstructured":"Euroimmun Medizinische Labordiagnostika AG. Anti\u2010PLA2R ELISA (IgG). Available from URL:http:\/\/www.pla2r.com\/fileadmin\/pla2r\/pdf\/Anti\u2010PLA2R\u2010ELISA\u2010_IgG__EN.pdf. Accessed 24 April 2015."}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12478","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:31:40Z","timestamp":1695573100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/nep.12478"],"URL":"https:\/\/doi.org\/10.1111\/nep.12478","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,21]]},"assertion":[{"value":"2015-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}