{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:52:58Z","timestamp":1774425178728,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Studies in animals show a relationship between extracellular volume and gastrointestinal motility. End\u2010stage renal disease (ESRD<\/jats:styled-content>) patients present fluid overload and frequent dyspeptic symptoms. We looked for an association between volaemic status and dyspepsia among ESRD<\/jats:styled-content> patients undergoing haemodialysis (HD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We studied 155 ESRD<\/jats:styled-content> patients on HD<\/jats:styled-content>. Their volaemic status was evaluated using bioimpedance analysis. Fluid overload (FO<\/jats:styled-content>) in litres and relative fluid overload (rFO<\/jats:styled-content>) in percentage were calculated. rFO<\/jats:styled-content>\u2009>\u200915% was classified as hypervolaemia. Dyspepsia was assessed through the P<\/jats:styled-content>orto A<\/jats:styled-content>legre D<\/jats:styled-content>yspeptic S<\/jats:styled-content>ymptoms Q<\/jats:styled-content>uestionnaire (PADYQ<\/jats:styled-content>). PADYQ<\/jats:styled-content> scores equal to or greater than 6 classified patients as dyspeptic. Characteristics of patients with and without dyspepsia were compared. P<\/jats:styled-content>earson's test was used to test the correlation between continuous variables. Multivariate linear and logistic regressions were performed to test FO<\/jats:styled-content> as predictor of dyspepsia score and the presence of dyspepsia.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 64 (41.2%) patients with dyspepsia. Dyspeptics presented higher FO<\/jats:styled-content> (2.5\u2009\u00b1\u20091.8 L vs<\/jats:italic> 1.0\u2009\u00b1\u20091.8 L; P<\/jats:italic>\u2009<\u20090.001) and higher rFO (16\u2009\u00b1\u20099.9% vs<\/jats:italic> 4.8\u2009\u00b1\u200912.0%; P<\/jats:italic>\u2009<\u20090.001). Dyspepsia score was positively correlated with FO<\/jats:styled-content> (r\u2009=\u20090.300; P<\/jats:italic>\u2009<\u20090.001) and with rFO<\/jats:styled-content> (r\u2009=\u20090.256; P<\/jats:italic>\u2009=\u20090.001). There were more patients with hypervolaemia among dyspeptics compared to non\u2010dyspeptics (65.6% vs<\/jats:italic> 17.6%; P<\/jats:italic>\u2009<\u20090.001). FO<\/jats:styled-content> was an independent predictor of dyspepsia score (b\u2009=\u20091.036; P<\/jats:italic>\u2009<\u20090.001) and the presence of dyspepsia (OR<\/jats:styled-content>\u2009=\u20092.00, 95% CI<\/jats:styled-content>\u2009=\u20091.55\u20132.50; P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Hypervolaemia is associated with dyspepsia among ESRD<\/jats:styled-content> patients on HD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12481","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T06:44:04Z","timestamp":1428561844000},"page":"519-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Volaemic status and dyspepsia in end\u2010stage renal disease patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Paulo Roberto","family":"Santos","sequence":"first","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"},{"name":"Dialysis Unit Santa Casa Hospital Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Levi Silveira","family":"Monteiro","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique Alexandre","family":"de Paula","sequence":"additional","affiliation":[{"name":"Dialysis Unit Santa Casa Hospital Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente Lopes","family":"Monte Neto","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Leilah Ponte Monte","family":"Coelho","sequence":"additional","affiliation":[{"name":"Dialysis Unit Santa Casa Hospital Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cec\u00edlia Costa","family":"Arcanjo","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e2nkia Maria Lopes","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Barbosa","family":"Gondim","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana\u00edna Teixeira Pereira Carneiro","family":"Tapeti","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyngridd Soares","family":"Mendes","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luise Vasconcelos","family":"Vieira","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia Parente","family":"Prado","sequence":"additional","affiliation":[{"name":"School of Medicine Sobral Campus Federal University of Cear\u00e1 Sobral Cear\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-004-9578-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-6-43"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12000"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.19094"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01321.x"},{"key":"e_1_2_7_8_1","first-page":"73","article-title":"Modifications of gastric compliance in dogs related to changes of extracelular fluid volume: A possible physiological role","volume":"16","author":"Capelo LR","year":"1983","journal-title":"Braz. 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