{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:26:39Z","timestamp":1783542399412,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,16]],"date-time":"2015-08-16T00:00:00Z","timestamp":1439683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["25860155"],"award-info":[{"award-number":["25860155"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Miyagi Kidney Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Peritoneal fibrosis is a serious complication in patients with end stage renal disease (<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>), especially those undergoing long\u2010term peritoneal dialysis therapy. Since the peritoneum is a major site of mast cell accumulation, and since mast cells are known to facilitate the progression of organ fibrosis, they would also contribute to the pathogenesis of peritoneal fibrosis. The aim of this study was to reveal the involvement of mast cells in the progression of peritoneal fibrosis in chronic renal failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a rat model with chronic renal failure (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>) resulting from 5\/6 nephrectomy, we examined the histopathological features of the rat peritoneum and compared them to those of age\u2010matched sham\u2010operated rat peritoneum. By treating the <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> rats with a potent mast cell stabilizer, tranilast, we also examined the involvement of mast cells in the progression of peritoneal fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> rat peritoneum was characterized by the wide staining of collagen <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and an increased number of myofibroblasts, indicating the progression of fibrosis. Compared to sham\u2010operated rat peritoneum, the number of toluidine blue\u2010stained mast cells was significantly higher in the fibrotic peritoneum of <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> rats. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of fibroblast\u2010activating factors and stem cell factor was significantly higher in peritoneal mast cells obtained from <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> rats than in those obtained from sham\u2010operated rats. Treatment with tranilast significantly suppressed the progression of peritoneal fibrosis in <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated for the first time that the number of mast cells was significantly increased in the fibrotic peritoneum of <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> rats. The proliferation of mast cells and their increased activity in the peritoneum were thought to be responsible for the progression of peritoneal fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12489","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T02:31:47Z","timestamp":1429237907000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mast cell involvement in the progression of peritoneal fibrosis in rats with chronic renal failure"],"prefix":"10.1111","volume":"20","author":[{"given":"Itsuro","family":"Kazama","sequence":"first","affiliation":[{"name":"Department of Physiology I Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Physiology I Tohoku University Graduate School of Medicine  Sendai Japan"},{"name":"Department of Plastic and Reconstructive Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Ejima","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Tohoku University Hospital  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunobu","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Center for Translational and Advanced Animal Research Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Tachi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,16]]},"reference":[{"issue":"4","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1177\/089686080002004S04","article-title":"Encapsulating peritoneal sclerosis: Definition, etiology, diagnosis, and treatment. 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