{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:29:58Z","timestamp":1789165798832,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401339"],"award-info":[{"award-number":["81401339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Project of Chongqing Science and Technology Commission","award":["cstc2014jcyjA10023"],"award-info":[{"award-number":["cstc2014jcyjA10023"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the clinical features and prognoses of children who develop reversible posterior encephalopathy syndrome (<jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content>) during treatment for nephrotic syndrome (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinicoradiological characteristics and prognoses of 51 patients with <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>, including 21 with <jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content> and 30 without, were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the controls, the <jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content> patients exhibited a higher rate of tacrolimus (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and cyclosporine (<jats:italic>P<\/jats:italic>\u2009=\u20090.02) treatment; higher\u2010dose prednisolone (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) treatment; higher systolic blood pressure (<jats:italic>P<\/jats:italic>\u2009=\u20090.04), serum cholesterol (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), and proteinuria (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01); and lower serum albumin levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). Hypertension was present in 85.7% of <jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content> patients. The clinical manifestations of <jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content> included an altered mental status, seizures, headaches, nausea and vomiting, and visual impairment. Electroencephalography findings included slow waves and focal sharp or\/and spiked waves; magnetic resonance imaging showed lesions localized in the occipital, parietal, frontal, temporal lobes and the cerebellum and brainstem; and magnetic resonance angiography revealed vertebral artery narrowing. All <jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content> patients recovered completely with timely and appropriate therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypertension, calcineurin inhibitor and high\u2010dose steroid treatments, high serum cholesterol and proteinuria levels, and low serum albumin levels can predispose children with <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">RPES<\/jats:styled-content>, although both the clinical and imaging outcomes are satisfactory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12518","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T20:37:39Z","timestamp":1432586259000},"page":"849-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reversible posterior encephalopathy syndrome in children with nephrotic syndrome"],"prefix":"10.1111","volume":"20","author":[{"given":"Juan","family":"Zhou","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Tang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Li","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0928"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.46"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1873-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-014-0350-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115073"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1264-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn013"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN106976"},{"key":"e_1_2_5_11_1","first-page":"163","article-title":"Posterior reversible encephalopathy syndrome in a child with steroid sensitive nephrotic syndrome","volume":"5","author":"Youssef D","year":"2012","journal-title":"Arab. J. Nephrol. Transplant."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0929"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-14"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22047"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e3181f31917"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.132216"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.14581\/jer.14008"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3487"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044534"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/25273221"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2301-y"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2014.04.014"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12518","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:46:32Z","timestamp":1695573992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/nep.12518"],"URL":"https:\/\/doi.org\/10.1111\/nep.12518","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]},"assertion":[{"value":"2015-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}