{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:31:03Z","timestamp":1781523063311,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Cinacalcet is effective in reducing parathyroid hormone (PTH<\/jats:styled-content>) in patients on dialysis. Reports of biochemical profiles and other clinical outcomes in patients discontinuing cinacalcet at time of renal transplantation are limited.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective study assessing markers of mineral metabolism, graft and patient outcomes in renal transplant recipients to determine differences in patients discontinuing cinacalcet (C<\/jats:styled-content>+) compared with patients not treated with cinacalcet (C<\/jats:styled-content>\u2212) at time of transplantation. To allow for differences between groups in pre\u2010transplant biochemical parameters, we also analysed a matched cohort of C<\/jats:styled-content>\u2212 with C<\/jats:styled-content>+ recipients (2:1), matched for age, calcium and PTH<\/jats:styled-content> levels at transplantation.<\/jats:p><\/jats:sec>Results<\/jats:title>Five hundred thirty\u2010two recipients (460 C<\/jats:styled-content>\u2212, 72 C<\/jats:styled-content>+), transplanted J<\/jats:styled-content>anuary 2006\u2013D<\/jats:styled-content>ecember 2012, were analysed, mean age 48.0\u2009\u00b1\u200912.7 years and 64.3% were men. At a median 42.9 months follow up, there were 10 deaths (1.9%), 56 allograft loss (10.6%) and 5 parathyroidectomies post\u2010transplant (0.8%). Median PTH<\/jats:styled-content> immediately pre\u2010transplant was higher in C<\/jats:styled-content>+ versus<\/jats:italic>\u2005C<\/jats:styled-content>\u2212 (50.7(25.4\u201375.2) versus<\/jats:italic> 28.3(13.9\u201349.7) pmol\/L, P<\/jats:italic>\u2009<\u20090.001). Twelve\u2010month post\u2010transplant PTH<\/jats:styled-content> was reduced but higher in C<\/jats:styled-content>+ (11.7(6.9\u201321.2) vs<\/jats:italic> 7.2(4.6\u201311.2) pmol\/L, P<\/jats:italic>\u2009<\u20090.001). Mean calcium was higher for C<\/jats:styled-content>+ versus<\/jats:italic>\u2005C<\/jats:styled-content>\u2212 at 12 months (2.50\u2009\u00b1\u20090.19 vs<\/jats:italic> 2.43\u2009\u00b1\u20090.17\u2009mmol\/L, P<\/jats:italic>\u2009<\u20090.001), with differences to 4 years post\u2010transplant. No difference was seen in renal function, graft loss, post\u2010transplant parathyroidectomy rate and mortality. In the matched cohort (144 C<\/jats:styled-content>\u2212 vs<\/jats:italic> 72 C<\/jats:styled-content>+), similar findings were also seen.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Differences in mineral metabolism post\u2010transplant are seen with cinacalcet pre\u2010transplant compared with no cinacalcet. Transplant recipients discontinuing cinacalcet had higher post\u2010transplant PTH<\/jats:styled-content> and calcium although the clinical significance is unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12536","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T14:20:40Z","timestamp":1433946040000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of cinacalcet pre\u2010transplantation on mineral metabolism in renal transplant recipients"],"prefix":"10.1111","volume":"21","author":[{"given":"Ashish K","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Masterson","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Holt","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven\u2010Jean","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavithra","family":"Jayadeva","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel D","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital Parkville Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1681\/ASN.V12102131","article-title":"Association of elevated serum PO4, Ca\u00d7 PO4 product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients","volume":"12","author":"Ganesh SK","year":"2001","journal-title":"J. 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