{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:01:51Z","timestamp":1788811311290,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270792"],"award-info":[{"award-number":["81270792"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81470939"],"award-info":[{"award-number":["81470939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170664"],"award-info":[{"award-number":["81170664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"State \u20181025\u2019 Science and Technology Support Projects","award":["2012BAI03B02"],"award-info":[{"award-number":["2012BAI03B02"]}]},{"DOI":"10.13039\/501100013286","name":"Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["20120101110018"],"award-info":[{"award-number":["20120101110018"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang Provincial Healthy Science Foundation of China","award":["WKJ2010-2-014"],"award-info":[{"award-number":["WKJ2010-2-014"]}]},{"name":"Zhejiang Provincial Healthy Science Foundation of China","award":["2012KYA119"],"award-info":[{"award-number":["2012KYA119"]}]},{"name":"Zhejiang Provincial Healthy Science Foundation of China","award":["2014KYA123"],"award-info":[{"award-number":["2014KYA123"]}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LH14H050002"],"award-info":[{"award-number":["LH14H050002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Approximately 30\u201340% of children with steroid sensitive nephrotic syndrome have frequently relapsing nephrotic syndrome (<jats:styled-content style=\"fixed-case\">FRNS<\/jats:styled-content>) or steroid\u2010dependent nephrotic syndrome (<jats:styled-content style=\"fixed-case\">SDNS<\/jats:styled-content>). Mycophenolate mofetil (<jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content>) and tacrolimus (<jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content>) are often alternative treatment choices for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center prospective study was conducted to compare the efficacy of <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> in reducing relapses and maintaining remission in children with <jats:styled-content style=\"fixed-case\">FRNS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SDNS<\/jats:styled-content>. Of the 72 recruited patients, either <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> (20\u223c30\u2009mg\/kg\/d, n\u2009=\u200934) or <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> (0.05\u223c0.15\u2009mg\/kg\/d, n\u2009=\u200938) was administered for 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean 6\u2010month relapse rates decreased from 2.56 episodes before therapy to 0.76 episodes in the first 6 months after therapy (c<jats:sup>2<\/jats:sup>\u2009=\u200944.362, p\u2009&lt;\u20090.001) and 0.67 in the next 6 months (c<jats:sup>2<\/jats:sup>\u2009=\u200937.817, p\u2009&lt;\u20090.001) in the <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> group. In the <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> group, the mean 6\u2010month relapse rates decreased from 2.39 episodes before therapy to 0.41 episodes in the first 6 months after therapy (c<jats:sup>2<\/jats:sup>\u2009=\u200962.242, p\u2009&lt;\u20090.001) and 0.42 in next 6 months (c<jats:sup>2<\/jats:sup>\u2009=\u200967.482, p\u2009&lt;\u20090.001). No significant difference in the relapse rate was found between the groups (before therapy, c<jats:sup>2<\/jats:sup>\u2009=\u20090.902, p\u2009=\u20090.637; first 6 months, c<jats:sup>2<\/jats:sup>\u2009=\u20095.358, p\u2009=\u20090.147; second 6 months, c<jats:sup>2<\/jats:sup>\u2009=\u20094.089, p\u2009=\u20090.252). And there was also no significant difference in cumulative sustained remission and the incidence of adverse events between two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In combination with low\u2010dose steroids, <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> presented similar efficacy in maintaining remission in children with <jats:styled-content style=\"fixed-case\">FRNS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SDNS<\/jats:styled-content> in the present study. Therapy with <jats:styled-content style=\"fixed-case\">MMF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">TAC<\/jats:styled-content> is a promising strategy with a moderate risk of side effects in children who are steroid sensitive but have <jats:styled-content style=\"fixed-case\">FRNS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SDNS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12537","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T14:21:00Z","timestamp":1433946060000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of mycophenolate mofetil or tacrolimus in children with steroid sensitive but frequently relapsing or steroid\u2010dependent nephrotic syndrome"],"prefix":"10.1111","volume":"21","author":[{"given":"Jingjing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Children's Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1825-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001533.pub3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002290.pub2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002290.pub4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V85769"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1877-x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1964-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00550206"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1300-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.08.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.12.083"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.11.081"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP65393"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000094133"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860221003606273"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36251-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2228-3"},{"key":"e_1_2_6_19_1","first-page":"33","article-title":"Tacrolimus in steroid resistant and steroid dependent childhood nephrotic syndrome","volume":"96","author":"Supavekin S","year":"2013","journal-title":"J. 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