{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:35:12Z","timestamp":1792211712002,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chinese 973 Project","award":["2012CB517702"],"award-info":[{"award-number":["2012CB517702"]}]},{"name":"Natural Science Fund of China to the Innovation Research Group","award":["81321064"],"award-info":[{"award-number":["81321064"]}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"crossref","award":["2012FFB03708"],"award-info":[{"award-number":["2012FFB03708"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Yichang City","award":["A13301-020"],"award-info":[{"award-number":["A13301-020"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To investigate the changing of idiopathic membranous nephropathy (iMN<\/jats:styled-content>) in C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study retrospectively analyzed renal disease spectrum of 6049 patients who underwent renal biopsy at P<\/jats:styled-content>eking U<\/jats:styled-content>niversity F<\/jats:styled-content>irst H<\/jats:styled-content>ospital from J<\/jats:styled-content>anuary 2003 to D<\/jats:styled-content>ecember 2012. The patients were grouped into two periods at a 5\u2010year interval: 2003\u20132007 (period 1) and 2008\u20132012 (period 2).<\/jats:p><\/jats:sec>Results<\/jats:title>Among 6049 renal biopsied patients, 3831 (63.3%) patients were diagnosed as primary glomerular disease (PGD<\/jats:styled-content>). The proportion of nephrotic syndrome (NS<\/jats:styled-content>) in PGD<\/jats:styled-content> was significantly higher in period 2 than that in period 1 (1016\/2214 [55.0%] vs<\/jats:italic> 682\/1617 [42.2%], P<\/jats:italic>\u2009=\u20090.022). The proportion of iMN<\/jats:styled-content> in PGD<\/jats:styled-content> increased from 16.8% (217\/1617) in period 1 to 29.35% (646\/2214) in period 2 in all groups of age (P<\/jats:italic>\u2009<\u20090.001). There was no significant difference of clinical characteristics including age, gender, hypertension, serum cholesterol and proteinuria between the two periods (P<\/jats:italic>\u2009>\u20090.05). However, in young patients with iMN<\/jats:styled-content> (14\u201344 years old), the percentage of renal histopathology stage I<\/jats:styled-content> and stage II<\/jats:styled-content> of iMN<\/jats:styled-content> in PGDs<\/jats:styled-content> was significantly higher in period 2 than that in period 1 (101\/1240 [8.15%] vs<\/jats:italic> 210\/1340 [15.7%], P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study suggests that the frequency of iMN<\/jats:styled-content> in PGD<\/jats:styled-content> in our referral diagnostic centre has doubled over the past 10 years. The increase of adult iMN<\/jats:styled-content> is mainly due to the increase of early stages of iMN<\/jats:styled-content> in young patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12542","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T10:13:39Z","timestamp":1434536019000},"page":"560-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Increasing frequency of idiopathic membranous nephropathy in primary glomerular disease: A 10\u2010year renal biopsy study from a single C<\/scp>hinese nephrology centre"],"prefix":"10.1111","volume":"20","author":[{"given":"Ping","family":"Zhu","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital Beijing China"},{"name":"Institute of Nephrology Peking University Beijing China"},{"name":"Key Laboratory of Renal Disease Ministry of Health of China Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China"},{"name":"Renal Division, Department of Medicine The First College of Clinical Medical Science China Three Gorges University Yichang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010de","family":"Zhou","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital Beijing China"},{"name":"Institute of Nephrology Peking University Beijing China"},{"name":"Key Laboratory of Renal Disease Ministry of Health of China Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital Beijing China"},{"name":"Institute of Nephrology Peking University Beijing China"},{"name":"Key Laboratory of Renal Disease Ministry of Health of China Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital Beijing China"},{"name":"Institute of Nephrology Peking University Beijing China"},{"name":"Key Laboratory of Renal Disease Ministry of Health of China Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China"},{"name":"Peking\u2010Tsinghua Center for Life Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine Peking University First Hospital Beijing China"},{"name":"Institute of Nephrology Peking University Beijing China"},{"name":"Key Laboratory of Renal Disease Ministry of Health of China Beijing China"},{"name":"Key Laboratory of CKD Prevention and Treatment Ministry of Education of China Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-2-200307150-00013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.17.2038"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn554"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi198"},{"key":"e_1_2_6_7_1","first-page":"442","article-title":"Prevalence of glomerular diseases: King Khalid University Hospital, Saudi Arabia","volume":"11","author":"Mitwalli AH","year":"2000","journal-title":"Saudi J. 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