{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:47:40Z","timestamp":1790012860116,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T00:00:00Z","timestamp":1453334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["455832"],"award-info":[{"award-number":["455832"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) have a significant burden of dyspnoea and fatigue in spite having normal left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>). Global longitudinal strain (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) can detect subtle changes in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function. This study aimed to evaluate the relationship between <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> function, functional capacity and quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients with preserved <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of patients with stage 3\/4 <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u2009108). Clinical characteristics, biochemical data, functional capacity (6\u2010min walk test (6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content>), timed up and go (<jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content>) test) and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> (short form\u201012 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012v2\u2122)\u2009) were measured. Echocardiogram was used to assess <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> and diastolic function (<jats:styled-content style=\"fixed-case\">E\/A<\/jats:styled-content>, e' and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\/e').<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 58.1\u2009\u00b1\u20099.9 years, 55.6% were men, estimated glomerular filtration rate was 44.8\u2009\u00b1\u200910.6\u2009<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>, <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> was \u221218.5\u2009\u00b1\u20093.6% and 19.4% had impaired <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> (&gt;\u221216%). Patients with impaired <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> had a significantly shorter 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> and slower <jats:styled-content style=\"fixed-case\">TUG<\/jats:styled-content> test compared with patients with preserved <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>. Bivariate analysis showed <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\/e' correlated with distance walked in 6<jats:styled-content style=\"fixed-case\">MWT (GLS<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.24, <jats:italic>P<\/jats:italic>\u2009=\u20090.02); <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\/e'(<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.38, <jats:italic>P<\/jats:italic>\u2009=\u20090.002)\u2009). Following adjustment for potential confounders, <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> remained independently associated with 6<jats:styled-content style=\"fixed-case\">MWT<\/jats:styled-content> (model <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.37, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Mean physical component summary scores (<jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>) and mental component summary scores (<jats:styled-content style=\"fixed-case\">MCS<\/jats:styled-content>) were 43.0\u2009\u00b1\u200910.2 and 50.9\u2009\u00b1\u20099.5. There was no cardiac parameter that was independently associated with <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>. However women, lower systolic blood pressure and <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> was associated with lower <jats:styled-content style=\"fixed-case\">MCS<\/jats:styled-content> (model <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.30, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> was associated with measures of functional capacity and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> patients with preserved <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12557","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T08:25:26Z","timestamp":1435825526000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association between left ventricular global longitudinal strain, health\u2010related quality of life and functional capacity in chronic kidney disease patients with preserved ejection fraction"],"prefix":"10.1111","volume":"21","author":[{"given":"Rathika","family":"Krishnasamy","sequence":"first","affiliation":[{"name":"Department of Renal Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel M","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haakan","family":"Strand","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodel","family":"Leano","sequence":"additional","affiliation":[{"name":"The University of Queensland at Princess Alexandra Hospital, Schools of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A","family":"Haluska","sequence":"additional","affiliation":[{"name":"The University of Queensland at Princess Alexandra Hospital, Schools of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S","family":"Coombes","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Research 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