{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T12:33:09Z","timestamp":1759667589042},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["25461618"],"award-info":[{"award-number":["25461618"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Henoch\u2010Sch\u00f6nlein purpura nephritis (HSPN<\/jats:styled-content>) is one of the most common types of chronic glomerulonephritis in children; however, there have been few reports on the pathogenesis and management of grade VI HSPN<\/jats:styled-content>. We present the case of a 6\u2010year\u2010old boy with grade VI HSPN<\/jats:styled-content> accompanied by severe nephrotic syndrome and hypocomplementaemia. Immunohistological studies revealed profound glomerular accumulation of CD<\/jats:styled-content>45\u2010 and CD<\/jats:styled-content>68\u2010positive inflammatory cells. Moreover, some cells expressed the proliferating marker proliferating cell nuclear antigen. His proteinuria and general oedema persisted despite repeated high\u2010dose steroid therapy; however, these clinical symptoms immediately improved after beginning treatment with cyclophosphamide (CyP<\/jats:styled-content>). Grade VI HSPN<\/jats:styled-content> was successfully treated with steroids and immunosuppressants. Among immunosuppressive drugs, CyP<\/jats:styled-content> was considered the most effective.<\/jats:p>","DOI":"10.1111\/nep.12558","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T08:26:17Z","timestamp":1450859177000},"page":"68-71","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Local leukocyte proliferation as a target for cyclophosphamide in the treatment of H<\/scp>enoch\u2010S<\/scp>ch\u00f6nlein purpura nephritis grade VI<\/scp>"],"prefix":"10.1111","volume":"21","author":[{"given":"Masahiro","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Pediatrics Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Ikezumi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utako","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2815-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.126"},{"key":"e_1_2_6_4_1","first-page":"463","volume-title":"Heptinstall's Pathology of the Kidney","author":"Haas M","year":"2015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-2070-z"},{"key":"e_1_2_6_6_1","first-page":"367","volume-title":"Immunologic Renal Diseases","author":"Hebert LA","year":"2001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.8.1638"},{"key":"e_1_2_6_8_1","first-page":"81","article-title":"A case of hypocomplementemic Henoch\u2010Sch\u00f6nlein purpura presenting features of membranoproliferative glomerulonephritis","volume":"48","author":"Lee KA","year":"2005","journal-title":"Korean J. Pediatr."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.21"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.07005.x"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12558","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:49:43Z","timestamp":1695538183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/nep.12558"],"URL":"https:\/\/doi.org\/10.1111\/nep.12558","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,23]]},"assertion":[{"value":"2015-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}