{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:37:30Z","timestamp":1778276250388,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Post\u2010transplant bone disease results from multiple factors, including previous bone and mineral metabolism disturbances and effects from transplant\u2010related medications. Bone biopsy remains the gold\u2010standard diagnostic tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We aimed to prospectively evaluate trabecular and cortical bone by histomorphometry after kidney transplantation. Seven patients, willing to perform follow\u2010up bone biopsy, were included in the study. Dual\u2010<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray absorptiometry and trans\u2010iliac bone biopsy were performed within the first 2 months after renal transplantation and repeated after 2\u20135 years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow\u2010up biopsy revealed a significant decrease in osteoblast surface\/bone surface (0.91\u2009\u00b1\u20090.81 to 0.47\u2009\u00b1\u20090.12%, <jats:italic>P<\/jats:italic>\u2009=\u20090.036), osteoblasts number\/bone surface (0.45 (0.23, 0.94) to 0.00\/mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009=\u20090.018) and erosion surface\/bone surface (3.75\u2009\u00b1\u20092.02 to 2.22\u2009\u00b1\u20091.38%, <jats:italic>P<\/jats:italic>\u2009=\u20090.044). A decrease in trabecular number (3.55 (1.81, 2.89) to 1.55\/mm (1.24, 2.06), <jats:italic>P<\/jats:italic>\u2009=\u20090.018) and increase in trabecular separation (351.65\u2009\u00b1\u2009135.04 to 541.79\u2009\u00b1\u2009151.91\u2009\u03bcm, <jats:italic>P<\/jats:italic>\u2009=\u20090.024) in follow\u2010up biopsy suggest loss in bone quantity. We found no significant differences in cortical analysis, except a reduction in external cortical osteonal eroded surface (5.76 (2.94, 13.97) to 3.29% (0.00, 6.67), <jats:italic>P<\/jats:italic>\u2009=\u20090.043). Correlations between bone histomorphometric and dual\u2010<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray absorptiometry parameters gave inconsistent results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results show a reduction in bone activity, suggesting increased risk of adynamic bone and loss of bone volume. Cortical bone seems less affected by post\u2010transplant biological changes in the first years after kidney transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12570","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T03:58:50Z","timestamp":1437623930000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evolution of bone disease after kidney transplantation: A prospective histomorphometric analysis of trabecular and cortical bone"],"prefix":"10.1111","volume":"21","author":[{"given":"Catarina","family":"Carvalho","sequence":"first","affiliation":[{"name":"Nephrology and Infectiology Research and Development Group INEB  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Nephrology and Infectiology Research and Development Group INEB  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Pereira","sequence":"additional","affiliation":[{"name":"Nephrology and Infectiology Research and Development Group INEB  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Sim\u00f5es\u2010Silva","sequence":"additional","affiliation":[{"name":"Nephrology Research and Development Unit Medical School Porto University  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Castro\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Nephrology Research and Development Unit Medical School Porto University  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Miguel","family":"Fraz\u00e3o","sequence":"additional","affiliation":[{"name":"Nephrology and Infectiology Research and Development Group INEB  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00589.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00938.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01950.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1532-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.3014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1161093"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00938.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(02)00078-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060105"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2358"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.309"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2942-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00460107"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1805"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0778-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-006-0053-z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111185"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12911"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182985468"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01100307"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027404"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006000100004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04151206"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.8289"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00445.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02423.x"},{"key":"e_1_2_7_29_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"113","author":"Moe SM","year":"2009","journal-title":"Kidney Int. 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