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This review discusses the role that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs play in murine models of immune\u2010mediated renal diseases and acute kidney injury and in human autoimmune kidney disease (such as systemic lupus erythematosus, anti\u2010glomerular basement membrane disease, anti\u2010neutrophil cytoplasmic antibody\u2010associated vasculitis). Current research suggests that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs may be reduced in number and\/or have impaired regulatory function in these diseases. <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs possess several mechanisms by which they can limit renal and systemic inflammatory immune responses. Potential therapeutic applications involving <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs include <jats:italic>in vivo<\/jats:italic> induction of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs or inducing <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs from na\u00efve <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells or expanding natural <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs <jats:italic>ex vivo<\/jats:italic>, to use as a cellular therapy. At present, the optimal method of generating a phenotypically stable pool of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs with long\u2010lasting suppressive effects is not established, but human studies in renal transplantation are underway exploring the therapeutic potential of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>regs as a cellular therapy, and if successful may have a role as a novel therapy in immune\u2010mediated renal diseases.<\/jats:p>","DOI":"10.1111\/nep.12574","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T07:26:06Z","timestamp":1437722766000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Regulatory <scp>T<\/scp> cells in immune\u2010mediated renal disease"],"prefix":"10.1111","volume":"21","author":[{"given":"Joanna R","family":"Ghali","sequence":"first","affiliation":[{"name":"Centre for 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