{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:37:38Z","timestamp":1787164658800,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Contrast\u2010induced\u2010nephropathy (CIN) is associated with poor outcomes, thus prevention of CIN may be of clinical value. Erythropoietin (EPO) has been shown to elicit tissue\u2010protective effects in experimental models and in clinical studies of acute kidney injury. We therefore evaluated its effectiveness for prevention of CIN after coronary angiography (CA) \u00b1 percutaneous coronary intervention (PCI) in diabetic patients with chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, randomized, controlled trial was carried out in 138 diabetic patients with eGFR &lt;60mL\/min who underwent non\u2010urgent CA \u00b1 PCI. Patients received normal saline and n\u2010acetyl cysteine before CA, with or without 50\u2009000\u2009U of EPO administered 30 min prior to CA. CIN was defined as an increase in serum creatinine of at least 0.5 mg\/dL during the first 2 days after exposure to contrast media. Primary outcome was the incidence of CIN. Secondary outcomes were the sensitivity and positive predictive value (PPV) of Cystatin C (CC) and Neutrophil\u2010gelatinase\u2010associated\u2010lipocalin (NGAL) for diagnosis of CIN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The observed incidence of CIN was 8.7%, significantly lower than the expected for such high\u2010risk population. The administration of EPO prior to CA did not reduce the incidence of CIN (9.7% vs. 7.6%,\n                      <jats:italic>P =<\/jats:italic>\n                      0.65). CC and NGAL demonstrated a low sensitivity (16.6%) and low PPV (6.7 and 33.3%, respectively) for detecting CIN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The administration of EPO prior to CA did not reduce the incidence of CIN. Additional prospective research with a larger sample size and in other patient categories is essential to further define the potential protective effect of EPO on prevention of CIN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nep.12609","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T07:41:06Z","timestamp":1442302866000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prevention of contrast\u2010induced nephropathy with single bolus erythropoietin in patients with diabetic kidney disease: A randomized controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Lilach","family":"Shema\u2010Didi","sequence":"first","affiliation":[{"name":"Quality Assurance Department Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batya","family":"Kristal","sequence":"additional","affiliation":[{"name":"Nephrology Department Galilee Medical Center  Nahariya Israel"},{"name":"Faculty of Medicine of the Galilee Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit","family":"Eizenberg","sequence":"additional","affiliation":[{"name":"Cardiology Department Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Marzuq","sequence":"additional","affiliation":[{"name":"Cardiology Department Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majdy","family":"Sussan","sequence":"additional","affiliation":[{"name":"Cardiology Department Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulie","family":"Feldman\u2010Idov","sequence":"additional","affiliation":[{"name":"Cardiology Department Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pnina","family":"Ofir","sequence":"additional","affiliation":[{"name":"Cardiology Department Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-5100","authenticated-orcid":false,"given":"Shaul","family":"Atar","sequence":"additional","affiliation":[{"name":"Cardiology Department Galilee Medical Center  Nahariya Israel"},{"name":"Faculty of Medicine of the Galilee Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2353041865"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000368"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.075"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.203.3.9169676"},{"key":"e_1_2_7_6_1","first-page":"460","article-title":"Contrast\u2010induced nephropathy among Israeli hospitalized patients: incidence, risk factors, length of stay and mortality","volume":"11","author":"Shema L","year":"2009","journal-title":"Isr. 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