{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:22:45Z","timestamp":1767828165694,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Gate's glomerular filtration rate (gGFR) measured by <jats:sup>99m<\/jats:sup>Tc\u2010DTPA renal dynamic imaging and estimated GFR (eGFR) estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD\u2010EPI) equation are two indexes used to evaluate renal function. However, little is known about whether gGFR can be used to accurately assess renal function in horseshoe kidney (HSK) patients with renal fusion anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen HSK patients (HSK group) diagnosed by renal imaging and 38 CKD patients with \u201cnormal kidney shape\u201d (non\u2010HSK group) matched to the HSK patients in terms of gender, age and biochemical indicators at Chinese PLA General Hospital were enrolled in this study. Gender, age, serum total protein (TP), albumin (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), gGFR and eGFR were recorded and analyzed using \u03c7<jats:sup>2<\/jats:sup> test, <jats:italic>t<\/jats:italic>\u2010test, and Wilcoxon test which was presented as median(IQR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) There were no significant differences in gender, age, TP, ALB, BUN, Scr, or eGFR between these two groups. (2) In HSK patients, the renogram showed abnormal renal axis with the lower poles orientated medially. The timed uptake curve showed that the isotope excretion in the HSK group was slower than that in the non\u2010HSK group. (3) For all HSK patients, gGFR was significantly lower than eGFR (range \u201312.52\u2009mL\/min per 1.73m<jats:sup>2<\/jats:sup> to \u201393.18\u2009mL\/min per 1.73m<jats:sup>2<\/jats:sup>). There was no significant difference in eGFR between the HSK [96.42 (36.02)\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup>] and non\u2010HSK groups [94.46 (33.00)\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup>]. The gGFR of the HSK group [41.18 (16.60)\u2009mL\/min per 1.73m<jats:sup>2<\/jats:sup>] was much lower than that of the non\u2010HSK group [86.42(26.40)\u2009mL\/min per 1.73m<jats:sup>2<\/jats:sup>, <jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001] and the eGFR of the HSK group (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.001). The gGFR and eGFR of the non\u2010HSK group were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>gGFR measured by <jats:sup>99m<\/jats:sup>Tc\u2010DTPA renal dynamic imaging is significantly lower than eGFR estimated by the CKD\u2010EPI equation, which indicates that isotope renogram cannot accurately evaluate the GFR of HSK patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12663","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T20:17:15Z","timestamp":1446236235000},"page":"499-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glomerular filtration rate measured by <sup>99m<\/sup>Tc\u2010DTPA renal dynamic imaging is significantly lower than that estimated by the CKD\u2010EPI equation in horseshoe kidney patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Yan","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Civil Aviation General Hospital  Beijing City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuansheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing City"},{"name":"Medical College Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing City"},{"name":"Medical College Nankai University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing City"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baixuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing City"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000092537.96414.4a"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64819-7"},{"key":"e_1_2_6_4_1","first-page":"e7","article-title":"Congenital renal anomalies detected in adulthood","volume":"8","author":"Muttarak M","year":"2012","journal-title":"Biomed. Imaging Interv. J."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-013-1229-7"},{"key":"e_1_2_6_6_1","first-page":"543","article-title":"Horseshoe kidney with retrocaval ureter: one case report","volume":"125","author":"Shen HL","year":"2012","journal-title":"Chin. Med. J. (Engl.)"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200305000-00007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140456"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2008.01950.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.34487"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0325-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062328"},{"key":"e_1_2_6_14_1","first-page":"458","article-title":"Differences between the CKD\u2010EPI and the MDRD equations when estimating the glomerular filtration rate in hypertensive patients","volume":"30","author":"Gomez Marcos MA","year":"2010","journal-title":"Nefrologia"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-011-9361-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl603"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.138.3.565"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-198309000-00003"},{"key":"e_1_2_6_19_1","first-page":"112","article-title":"99mTc\u2010DTPA scintillation\u2010camera renography: a new method for estimation of single\u2010kidney function","volume":"18","author":"Nielsen SP","year":"1977","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4274\/MIRT.20.03"},{"key":"e_1_2_6_21_1","first-page":"137","article-title":"Renal uptakes of 99mTc\u2010MAG3, 99mTc\u2010DTPA, and 99mTc\u2010DMSA in rabbits with unilateral ureteral obstruction","volume":"24","author":"Lee WG","year":"2010","journal-title":"In Vivo"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079675"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040368"},{"key":"e_1_2_6_24_1","first-page":"1211","article-title":"Methods for measuring GFR with technetium\u201099m\u2010DTPA: an analysis of several common methods","volume":"31","author":"Mulligan JS","year":"1990","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_25_1","first-page":"372","article-title":"Measurement of glomerular filtration rate with technetium\u201099m DTPA: comparison of plasma clearance techniques","volume":"28","author":"Waller DG","year":"1987","journal-title":"J. Nucl. Med."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.remn.2009.07.005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.02.344"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900624"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.12.016"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.03.026"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.11.007"}],"container-title":["Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnep.12663","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12663","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nep.12663","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nep.12663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:29:32Z","timestamp":1696156172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nep.12663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/nep.12663"],"URL":"https:\/\/doi.org\/10.1111\/nep.12663","archive":["Portico"],"relation":{},"ISSN":["1320-5358","1440-1797"],"issn-type":[{"value":"1320-5358","type":"print"},{"value":"1440-1797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]},"assertion":[{"value":"2015-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}