{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:46:41Z","timestamp":1770666401763,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundation of Guangdong Province, China","award":["2015A030313045"],"award-info":[{"award-number":["2015A030313045"]}]},{"name":"Science and Technology Planning Project of Guangdong Province, China","award":["2014A020212140"],"award-info":[{"award-number":["2014A020212140"]}]},{"name":"National Innovation Training Program Project for College Students","award":["201310558086"],"award-info":[{"award-number":["201310558086"]}]},{"name":"Innovation Training Program Project for College Students of Guangdong Province","award":["201410558266"],"award-info":[{"award-number":["201410558266"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to investigate the clinicopathologic characteristics of biopsy\u2010proven childhood renal diseases and to compare the trends and changes during two different time intervals between 1984 and 2011 at the First Affiliated Hospital of Sun Yat\u2010sen University in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed kidney biopsy data from children with renal diseases and compared the data during two time intervals, namely 1984\u20131997 and 1998\u20132011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1313 children were enrolled in the present study. There were 921 children with primary glomerular disease (PGD) and 312 children with secondary glomerular disease (SGD), accounting for 70.1% and 23.8% of participants, respectively. The major clinical manifestation of PGD was nephrotic syndrome (NS), which accounted for 31.2% of cases, while the main aetiology of SGD was lupus nephritis (40.7%). The main biopsy patterns of PGD were IgA nephritis (27.6%), minimal change disease (24.0%), and mesangial proliferative glomerulonephritis (16.9%). PGD was the major class of disease in both time intervals, but the ratio of PGD decreased over time, while the ratio of SGD and other glomerular diseases increased. PGD was also the major class of disease in each age group; however, the incidence of PGD decreased with increasing age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence patterns of paediatric renal diseases changed over the 28\u2010year period of this study. Our results show that different renal diseases characterize different age intervals. Furthermore, there are several associations between clinical presentation and biopsy features in childhood renal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12702","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T03:38:41Z","timestamp":1450928321000},"page":"1003-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Twenty\u2010eight\u2010year review of childhood renal diseases from renal biopsy data: A single centre in China"],"prefix":"10.1111","volume":"21","author":[{"given":"Mengjie","family":"Jiang","sequence":"first","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zizheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Sun Yat\u2010sen University Cancer Centre Guangzhou 510060 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Rong","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Mo","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangzhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinic Medicine Sun Yat\u2010Sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510080 Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1419"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.144307"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-0927-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.111833"},{"key":"e_1_2_6_6_1","first-page":"746","article-title":"clinical classification, diagnosis and treatment of glomerular diseases in children. 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