{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:26:02Z","timestamp":1769174762445,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Nephrology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In<jats:italic>Plasmodium falciparum<\/jats:italic>malaria, the clinical manifestation of acute kidney injury (AKI) is commonly associated with acute tubular necrosis (ATN) in the kidney tissues. Renal tubular cells often exhibit various degrees of cloudy swelling, cell degeneration, and frank necrosis. To study individual cell death, this study evaluates the degree of renal tubular necrosis in association with apoptosis in malarial kidneys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Kidney tissues from<jats:italic>P. falciparum<\/jats:italic>malaria with AKI (10 cases), and without AKI (10 cases) were evaluated for tubular pathology. Normal kidney tissues from 10 cases served as controls. Tubular necrosis was assessed quantitatively in kidney tissues infected with<jats:italic>P. falciparum<\/jats:italic>malaria, based on histopathological evaluation. In addition, the occurrence of apoptosis was investigated using cleaved caspase\u20103 marker. Correlation between tubular necrosis and apoptosis was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tubular necrosis was found to be highest in<jats:italic>P. falciparum<\/jats:italic>malaria patients with AKI (36.44% \u00b1 3.21), compared to non\u2010AKI (15.88% \u00b1 1.63) and control groups (2.58% \u00b1 0.39) (all<jats:italic>p<\/jats:italic>&lt; 0.001). In the AKI group, the distal tubules showed a significantly higher degree of tubular necrosis than the proximal tubules (<jats:italic>p<\/jats:italic>= 0.021) and collecting tubules (<jats:italic>p<\/jats:italic>= 0.033). Tubular necrosis was significantly correlated with the level of serum creatinine (<jats:italic>r<\/jats:italic>= 0.596,<jats:italic>p<\/jats:italic>= 0.006), and the occurrence of apoptosis (<jats:italic>r<\/jats:italic>= 0.681,<jats:italic>p<\/jats:italic>= 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In malarial AKI, the process of apoptosis occurs in ATN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nep.12715","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T08:22:36Z","timestamp":1451982156000},"page":"79-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Expression of cleaved caspase\u20103 in renal tubular cells in<i>Plasmodium falciparum<\/i>malaria patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Benjamas","family":"Wichapoon","sequence":"first","affiliation":[{"name":"Department of Tropical Pathology Faculty of Tropical Medicine, Mahidol University 420\/6 Rajvithi Road Bangkok 10400 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuchard","family":"Punsawad","sequence":"additional","affiliation":[{"name":"School of Medicine Walailak University, 222 Thasala District Nakhon Si Thammarat 80161 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parnpen","family":"Viriyavejakul","sequence":"additional","affiliation":[{"name":"Department of Tropical Pathology Faculty of Tropical Medicine, Mahidol University 420\/6 Rajvithi Road Bangkok 10400 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"World Malaria Report 2014","author":"WHO","year":"2014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60021-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/341057a0"},{"key":"e_1_2_5_5_1","first-page":"1057","article-title":"An immunohistochemical study of the pathology of fatal malaria. 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